Rosmarinus officinalis (rosemary) oil is widely used by the cosmetic, food, and pharmaceutical industries as a fragrance component of soaps, creams, lotions, and perfumes. Although it is popular, potential harmful side-effects of the oil have been described. We investigated the genotoxic and mutagenic potential of essential oil of R. officinalis in rodents, using comet, micronucleus and chromos...

Chromosome examinations were made both in cultured peripheral lymphocytes and in freshly aspirated bone marrow cells of 6 persons accidentally exposed to gamma rays from an 192Ir. Samplings of peripheral blood for the chromosome analysis were repeated mostly at weekly in tervals during the hospitalization beginning on 10-11 days after the initial exposure, and at more prolonged intervals after ...

The clastogenic effect of total dichloromethane, methanol and water extracts, four bioactive fractions and three individual constituents from Carthamus lanatus aerial parts were evaluated in mice by bone marrow chromosome aberration assay with mitomycin C as positive control. Significant differences in the percentage of aberrant mitosis of the extracts were observed. The dichloromethane extract...

We report a dysmorphic boy with a de novo partial trisomy 1q. The boy has microcephaly, bilateral cleft lip and palate, low set and dysmorphic ears, brain anomalies, pulmonary stenosis, duodenal obstruction, dysplastic kidneys, and bifid thumbs. The trisomic segment 1q32-qter is duplicated with an inverted insertion at 1p36.3. The aberration was initially detected at amniocentesis and confirmed...

In 1964 de Grouchy, Royer, Salmon, and Lamy described a deaf and mentally retarded microcephalic girl in whom the long arm of one No. 18 chromosome was about half its usual length. Since then two other microcephalic children, a boy and a girl, have been found to have this chromosome aberration (Lejeune, Berger, Lafourcade, and R6thore, 1966). Lejeune suggested on the basis of their findings tha...

. Twenty-four men and 24 women, all nonsmoking, and maintaining normal dietary habits were assigned to 3 groups of 16. Each group comprising 4 males with “low” cholesterol levels (<6 mmol/L) matched for age and build with 4 males with “high” cholesterol levels (>6 mmol/L) and 8 similarly matched females. A three-treatment, three-treatment period, cross-over design was adopted. The three treatme...

As a part of technical improvements of chromosome aberration analysis on human peripheral lymphocytes for biological radiation dosimetry, we examined the optimal conditions for the use of colcemid in chromosome preparation in order to obtain enough number of cells at metaphase in the first cell division. When treated with colcemid at concentrations below 0.01 microgram/ml from the beginning of ...

The brown seaweed Fucus vesiculosus (Fucales, Fucaceae) was screened for its protective activity using doxorubicin-induced DNA damage in human lymphocytes. In this study, we assessed the genotoxic and antigenotoxic potential of three different concentrations (0.25, 0.5 and 1.0 mg mL) of F. vesiculosus aqueous extract using the chromosome aberration and Comet assays. Treatment of human lymphocyt...

Chromosome aberration analyses were performed on blood samples from 165 active underground uranium miners between 1981 and 1985. After decommissioning the mine in 1997 chromosome aberration analyses were also included in the medical laboratory investigations of health conditions of 141 subjects between 1998 and 2002 within the framework of a follow-up-study. The numerical data are presented as ...

The frequencies of chromosomal aberrations in Giemsa-bar:ded preparations obtained from peripheral blood cultures of 5 kwashiorkor, 3 marasmic and 2 marasmickwashiorkor patients were investigated. Analysis of 1120 metaphases from these patients revealed an aberration rate of 5. 80 per cent as against a frequency of 1. 66 per cent seen in control children. However, no particular chromosome or ch...