chromosome 9p21

Juyong Brian Kim Andres Deluna Imran N Mungrue Christine Vu Delila Pouldar Mete Civelek Luz Orozco Judy Wu Xuping Wang Sarada Charugundla Lawrence W Castellani Marta Rusek Hieronim Jakubowski Aldons J Lusis

BACKGROUND The human 9p21.3 chromosome locus has been shown to be an independent risk factor for atherosclerosis in multiple large-scale genome-wide association studies, but the underlying mechanism remains unknown. We set out to investigate the potential role of the 9p21.3 locus neighboring genes, including Mtap, the 2 isoforms of Cdkn2a, p16Ink4a and p19Arf, and Cdkn2b, in atherosclerosis usi...

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The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells.

Journal: :Somatic cell and molecular genetics 1993

B W Porterfield H Pomykala E Maltepe S K Bohlander J D Rowley M O Diaz

Methylthioadenosine phosphorylase (MTAP) is an enzyme that functions in a salvage pathway for adenine synthesis. The locus that encodes MTAP activity has been mapped to human chromosome 9 (9q12-9pter) by analysis of mouse x human somatic cell hybrids. Cells that have MTAP activity will stop proliferating, and eventually die in the presence of azaserine, an inhibitor of de novo purine synthesis,...

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