نتایج جستجو برای: chromosome 16
تعداد نتایج: 446673 فیلتر نتایج به سال:
A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse
The establishment of three cell lines from keratinizing and nonkeratinizing cervical carcinomas was previously reported. These cell lines were analyzed for growth properties in vitro and in vivo. Metaphases prepared from tissue culture of these cell lines were cytogenetically characterized using GTG-banding and fluorescent in situ hybridization (FISH) using chromosome-specific alpha-satellite p...
Current models suggest that genomic instability is crucial in the accumulation of the multiple alterations required for tumorigenesis. However, the nature of the initial damage responsible for the origin of genomic instability remains poorly understood. In this investigation we demonstrate that the nucleotide analog 2,6-diaminopurine (DAP) can be used to induce highly focused damage to the larg...
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