نتایج جستجو برای: chromosomal instability

تعداد نتایج: 133476  

2017
Saffiyeh Saboor Maleki Christoph Röcken

Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the total cancer incidence. The prognosis of GC is dismal in Western countries due to late diagnosis: approximately 70% of the patients die within 5 years following initial diagnosis. Recently, integrative genomic analyses led to the proposal of a molecular classification of GC into four subtypes, i.e.,micro...

Journal: :Current Biology 2003
Franziska Michor Yoh Iwasa Natalia L Komarova Martin A Nowak

Tissues of long-lived multicellular organisms have to maintain a constant number of functioning cells for many years. This process is called homeostasis. Homeostasis breaks down when cells emerge with mutations in tumor suppressor genes or oncogenes. Such mutated cells can have increased net rates of proliferation, which is increased somatic fitness. We show that the best protection against suc...

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