نتایج جستجو برای: chordoma
تعداد نتایج: 1277 فیلتر نتایج به سال:
Chordomas are rare primary bone tumors that occur along the neuraxis. Primary treatment is surgery, often followed by radiotherapy. Treatment options for patients with recurrence are limited and, notably, there are no FDA approved therapeutic agents. Development of therapeutic options has been limited by the paucity of preclinical model systems. We have established and previously reported the i...
BACKGROUND Chordomas are rare tumors of the axial skeleton for which surgical resection remains the most reliable means of cure. PI-103 is a inhibitor of PI3K/AKT and mTOR activation. This study aims to determine whether the PI3K/mTOR pathway was active in chordomas and whether their inhibition could lead to decreased proliferation and increased apoptosis. MATERIALS AND METHODS Thirteen human...
OBJECTIVE To evaluate the efficacy and toxicity of fractionated stereotactic radiotherapy (FSRT) for chordoma and chondrosarcoma. METHODS Twenty consecutive patients with a histopathologic diagnosis of chordoma (n = 16) or chondrosarcoma (n = 4) treated between 2010 and 2016 were retrospectively identified. All patients underwent FSRT in five fractions to a median dose of 37.5 Gy (range: 25-4...
Abstract Introduction/Objective Chordoma originates from remnants of the embryonal notochord, and arise in bones anywhere along spine skull base. The most common location was thought to be sacrum, followed by clivus, a much lesser extent rest spine. However, some studies have suggested an equal distribution among base (32%), mobile (32.8%), sacro-coccygeal (29.2%). Here we report case chordoma ...
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