Human serum aryl acylamidase associated with serum cholinesterase was purified to homogeneity. Evidence for the identity of the two enzymes was based on co-elution profiles, co-purification in the different steps including affinity chromatography with constant ratios of specific activity and percentage recoveries, co-migration on gel electrophoresis, parallel inhibition by typical cholinesteras...

Alzheimer's disease (AD) is a devastating syndrome that accounts for 60–70 % of all dementia cases, putting an enormous burden on global healthcare and economy. Unfortunately, there no cure AD, the currently approved drugs are limited in their effects. Given various pathological mechanisms behind “one-target, one-drug” paradigm drug design became obsolete, new paradigm, polypharmacology, emerge...

BACKGROUND Cholinesterase inhibitors are commonly prescribed to treat dementia, but their adverse effect profile has received little attention. These drugs can provoke symptomatic bradycardia and syncope, which may lead to permanent pacemaker insertion. Drug-induced syncope may also precipitate fall-related injuries, including hip fracture. METHODS In a population-based cohort study, we inves...

organophosphate chronic toxicity has been evaluated in this study. biological screening for organophosphate insecticide-exposed workers is mostly recommended for mixers, loaders, formulators and spraymen. we have studied 17 occupationally exposed persons to pesticides. using ellman's colorimetric method, their plasma cholinesterase activities have been measured. results show that the appea...

For 6 months after renal transplant serum cholinesterase concentrations were measured in 10 patients. The value decreased in the first 15 days after operation, but was normal thereafter. Liver function tests were normal throughout the study; the cholinesterase changes were independent of immunosuppressive therapy.

Arsenic is an environmental toxicant, and one of the major mechanisms by which it exerts its toxic effect is through an impairment of cellular respiration by inhibition of various mitochondrial enzymes, and the uncoupling of oxidative phosphorylation. Most toxicity of arsenic results from its ability to interact with sulfhydryl groups of proteins and enzymes, and to substitute phosphorus in a v...

biomarkers are assigned as early warning systems regarding aquatic organisms exposed to pollutants. among which, however, measurement of esterase enzymes activity specially cholinesterase of fish tissues, is a marker for exposure to organophosphate pesticide and carbamates, and this biomarker has been used widely in broad range of investigations. a number of capoeta capoeta gracilis (:cyprinida...

In 1986, Whittaker wrote ‘Churchill-Davidson’s editorial entitled “The succinylcholine story” in 1963, highlighted probably for the first time in the UK, the role of serum protein polymorphism in drug sensitivity’ [1]. Following a series of detailed family studies, in 1959 Kalow [2] concluded that individuals who had prolonged apnoea following succinylcholine administration were homozygous for ...

Organophosphate chronic toxicity has been evaluated in this study. Biological screening for organophosphate insecticide-exposed workers is mostly recommended for mixers, loaders, formulators and spraymen. We have studied 17 occupationally exposed persons to pesticides. Using Ellman's colorimetric method, their plasma cholinesterase activities have been measured. Results show that the appear...