Pulse-chase incubations of human plasma with [3H]cholesterol-laden skin fibroblasts or low density lipoproteins (LDL) and nondenaturing two-dimensional electrophoresis were used to study the transfer and esterification of cell-derived unesterified cholesterol (UC) in human plasma lipoproteins. Specific radioactivities ([3H]UC per microgram of UC) were calculated, and net cholesterol mass transf...

High-density lipoproteins (HDLs) represent a spectrum of particles that vary in their physicochemical and functional properties.' It has been shown in many population studies that the concentration of HDL cholesterol (HDL-C) is inversely related to the risk of having a cardiovascular disease (CVD) event. In this paradigm, HDL-C has been considered to be a marker of the potentially cardioprotect...

A lthough low levels of high-density lipoprotein cholesterol (HDL-C) represent a strong independent risk marker inversely associated with cardiovascular disease (CVD), large interventional trials have failed to translate the increases in HDL-C into reductions in cardiovascular events. As HDL plasma levels represent a pool of the different HDL subfractions, which may vary in their structure and ...

Serum high density lipoprotein (HDL) cholesterol and other lipoproteins were measured in 27 TIA-patients with a mean age of 49 +/- 10 years before and during phenytoin therapy. The pretreatment concentrations of HDL-cholesterol (mmol/l, mean +/- SD) were lower (p less than 0.001) in male (1.03 +/- 0.25) and in female patients (1.15 +/- 0.44) than in healthy male (1.28 +/- 0.34) and female contr...

In general, Indians have low HDL cholesterol levels. Fenofibrate, a drug widely used in the treatment of hypertriglyceridemia, usually also increases HDL cholesterol. There have been a few reports in the literature of a paradoxical decrease in serum HDL-cholesterol in patients treated with fenofibrate, either alone or in combination with a statin. We report three cases of paradoxical decrease i...

BACKGROUND Decreased high-density lipoprotein (HDL) cholesterol levels constitute a major risk factor for coronary heart disease; however, there are no therapies that substantially raise HDL cholesterol levels. Inhibition of cholesteryl ester transfer protein (CETP) has been proposed as a strategy to raise HDL cholesterol levels. METHODS We conducted a single-blind, placebo-controlled study t...

Hijamah or cupping therapy has a therapeutic effect on cholesterol. However, there is still lack of studies that investigate the potential in managing apolipoprotein B as proatherogenic agent and A-1 an anti-proatherogenic agent. This study aims to explore lipid profiles apolipoproteins hypercholesterolemic patients. A pre-post experimental design without controls were used. Consecutive samplin...

High-density lipoproteins (HDL) are thought to be cardioprotective due to their role in decreasing cholesterol accumulation and in enhancing cholesterol removal from foam cells. Our study will examine foam cell formation and HDL-mediated cholesterol removal from macrophages isolated from patients with hypertriglyceridemia and low HDL. Peripheral blood monocytes and lipoproteins will be isolated...

Objective: Brown fat activation attenuates atherosclerosis development by accelerating triglyceride-rich lipoprotein turnover and/or stimulation of reverse cholesterol transport via the SRB1 (scavenger receptor class B type 1). The aim this study was to investigate specific role hepatic in atheroprotective properties brown activation. Approach and Results: APOE*3-Leiden.CETP mice, a well-establ...

The effect of the type of dietary fat on the concentrations and compositions of high density lipoprotein (HDL) subpopulations was studied in groups of African green monkeys consuming 40% of calories as fat supplied as saturated fat (P/S = 0.3) or polyunsaturated fat (P/S = 2.2) in the presence of either 0.8 mg or 0.03 mg cholesterol/kcal. Plasma HDL cholesterol concentrations were lower in poly...