Cholesteatoma is a collection of keratinous debris and stratified squamous epithelium. It is trapped in the middle ear and can lead to bony erosion. The disease is treated surgically often followed by a second-look procedure to check for residual tissue or recurrence. Cholesteatoma has specific signal-intensity characteristics on magnetic resonance imaging with very high signal intensity on dif...

A rare case of congenital cholesteatoma as a cause of acute labyrinthitis is presented in the report. 14-years old boy was operated due to labyrinthitis caused by a huge cholesteatoma discovered behind intact tympanic membrane. On the first examination the symptoms indicated lack of right inner ear function, so unfortunately the referral was to late and the patient resulted in the dead ear. The...

Transcanal endoscopic ear surgery (TEES) is being increasingly used in chronic ear disease for cholesteatoma removal and middle ear reconstruction, reducing the need for a postauricular incision and mastoidectomy. However, TEES is a challenging technique even for the most experienced otologist, requiring one-handed dissection using angled instrumentation. We have therefore developed a high-fide...

INTRODUCTION Chronic cholesteatoma otitis media, apart from destruction of bones and possibility of otogenous complications, is characterized by possibility of recurrence of the disease after non radical treatment or presence of risk factors. AIM This paper intends to analyze changes typical for cholesteatoma, observed during otosurgery including the results of bacteriological investigations....

Introduction: In developing countries, chronic otitis media (COM) and cholesteatoma are relatively prevalent.  Within the field of otology, COM surgery remains one of the most common surgical treatments. Most recent studies evaluating the potential prognostic factors in COM surgery have addressed graft success rate and types of middle ear and mastoid pathology. There has been much controversy a...

Hypothesis: We hypothesized that an anomalous change of Notch signaling might be involved in the pathophysiology cholesteatoma. Background: The pathway regulates integrated growth and differentiation control keratinocytes. Its involvement cholesteatoma proliferation has not been elucidated. Methods: obtained external auditory canal (EAC) skin samples from patients with middle ear who underwent ...

OBJECTIVE To review recent biomolecular advances in etiopathogenesis of acquired cholesteatoma. DATA SOURCES MEDLINE via OVID (to March 2014) and PubMed (to March 2014). REVIEW METHODS All articles referring to etiopathogenesis of acquired cholesteatoma were identified in the above databases, from which 89 articles were included in this review. RESULTS The mechanisms underlying the etiopa...

Objectives: The objective of the study was to detect and analyze the bacteriological profile in cases of chronic suppurative otitis media with cholesteatoma and to assess the commonest organism found in cases of chronic suppurative otitis media with cholesteatoma. Material and methods: A total of 75 cases of chronic suppurative otitis media with cholesteatoma were admitted in E.N.T. Unit-1, May...

UNLABELLED Acquired middle ear cholesteatoma is a disease which promotes bone erosion resulting in potentially serious complications. The tumor necrosis factor alpha (TNF-α) is present in cholesteatoma and it is related to bone erosion, as shown by different authors. To understand the aggressiveness characteristics of cholesteatoma is necessary, however, to better address the presence and distr...

OBJECTIVE To describe and quantify growth patterns of cholesteatomas within the middle ear using a scaled rating system that characterizes patterns of ossicular erosion. STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. PATIENTS Patients undergoing first-time surgery for primary and secondary acquired cholesteatomas. INTERVENTIONS Intraoperative assessments of os...