P-glycoprotein, encoded by the MDR1 gene, plays an important role in the absorption, distribution, metabolism, and excretion of many drugs.Thus it is not surprising that lack of P-glycoprotein, which occurs in many herding-breed dogs, leads to increased susceptibility to drug toxicosis (e.g., use of ivermectin and other drug sensitivities in collies). By using a genetic test, it is now possible...

From the perspective of product uncertainty, the effect of product type, product price and sales on buyer’s online payment method choice was explored with a 2 price levels (high vs. low) × 2 sales levels (high vs. low) × 2 product types (experience vs. search) within-subjects eye-tracking experiment. Thirty voluntary participants from Zhejiang University participated in the experiment. The dete...

Enantiomer separation represents an important topic especially in pharmaceutical and environmental fields where many drugs and pesticides are racemic compounds. In some cases, only one of the enantiomers has pharmacological or pesticidal activity while the other may exhibit antagonistic activities, unwanted side effects or even toxic effects. Therefore, the development of new enantioseparation ...

Beliefs about relative skill matter for risky decisions such as career choices, market entry, and financial investments. Yet in most laboratory experiments risk is exogenously given and beliefs about relative skill play no role. We use a laboratory experiment free of strategy confounds to isolate the impact of beliefs about relative skill on risky choices. We find that low (high) skill individu...

A capillary electrophoresis method was used for assay of some degradation products of carvedilol. The optimized parameters were as; running buffer 80 mM acetate dissolved in methanol/ethanol mixture (65:35 v/v), applied voltage of 19 kV, temperature is 20 ºC and the wavelength range of 200-350 nm. The results indicate that the proposed CE method could effectively separate carvedilol from its de...

The binding of N-heterocyclic carbenes to Ce(III) and U(III) compounds is characterized by quantum chemical methods. Density functional methods are in qualitative agreement with experiment that binding to U(III) is more favorable than to Ce(III); after correcting for basis-set superposition error, quantitative agreement with experiment is achieved with a multireference second-order perturbation...