OBJECTIVES Therapy of AIDS patients infected with Mycobacterium avium is problematic due to its intrinsic resistance to antibiotics. We have characterized the efflux pump activity of M. avium wild-type strain through an automated fluorometric method and correlated it with intrinsic resistance to antibiotics. METHODS M. avium ATCC 25291(T) and Mycobacterium smegmatis mc(2)155 were evaluated fo...

Objective: To study ocular manifestations in patients who were on long-term use of chlorpromazine. Methods: A retrospective observational case study was made. Three patients, who were diagnosed as Schizophrenia and on long-term use of chlorpromazine for more than 20 years, were examined retrospectively. The examinations included clinical history, physical examination, slit-lamp biomicroscopy, a...

Background: Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. Methods: Albino Wistar r...

BACKGROUND The aim was to compare the efficacy and safety of a combination of intramuscular ketorolac and chlorpromazine for the treatment of acute exacerbations of chronic pain with the more commonly used regimen of intramuscular meperidine and promethazine. METHODS Use-effective case series were drawn from a real-life, rural emergency department practice, in which 200 consecutive patients c...