Herein, we developed the photosensitizer, protoporphyrin IX (PpIX), conjugated glycol chitosan (GC) nanoparticles (PpIX-GC-NPs) as tumor-homing drug carriers with cellular on/off system for photodynamic imaging and therapy, simultaneously. In order to prepare PpIX-GC-NPs, hydrophobic PpIXs were chemically conjugated to GC polymer and the amphiphilic PpIX-GC conjugates formed a stable nanopartic...

Vitamin supplementation during chemotherapy has often been associated with lower recurrence and mortality rates in cancer patients. We had previously demonstrated that the multivitamin (C, D3, B12)–cisplatin nanoparticle complex—NanoCisVital (NCV)—could alleviate chemotherapy-induced fatigue. Chitosan is frequently used functional nanomaterials to encapsulate drugs, because it biodegradable, bi...

SiRNA-based strategies appear to be an exciting new approach for the treatment of respiratory diseases. To extrapolate siRNA-mediated interventions from bench to bedside in this area, several aspects have to be jointly considered, including a safe and efficient gene carrier with pulmonary deposition efficiency, as well as in vivo method for siRNA/nanoparticles delivery. Accordingly, in this wor...

Abstract Background The distribution of drugs could not be controlled in the conventional delivery systems. This has led to developing a specific nanoparticle-based system, called smart drug In cancer therapy, innovative biocompatible nanocarriers have received much attention for various ranges anti-cancer drugs. this work, effect an interesting and novel copolymer named "dimethyl acrylamide-tr...

Objective: Formulation and evaluation of clobetasol-17-propionate-loaded carboxymethyl chitosan nanoparticle. Psoriasis is a chronic skin disorder caused due to the autoimmune factors. It has detrimental psychological physiological impact on patients emergence apparent skin. The systemic therapy with anti-psoriatic drugs such corticosteroids, immunosuppressant, gene suppressors causes severe si...

In this study, a simple, rapid, and environmentally friendly green approach for synthesizing Fe 3 O 4 /chitosan nanoparticles with various concentrations was developed. The had spherical shape cubic inverse spinel structure. functionalization of the using chitosan increased crystallite size from 7.2 to 7.8 nm. Fourier transform infrared spectra showed existence characteristic peaks in addition ...

The polymeric nanoparticles are prepared from biocompatible polymers in size between 10-1000 nm. Chitosan is a biocompatible polymer that - can be utilized as drug delivery systems. In this study, chitosan nanoparticles were synthesized using an optimized spontaneous emulsification method. Determining particle size and morphology are two critical parameters in nanotechnology. The aim of this st...

Aquatic toxicity testing generally focuses on the water absorption/dermal route of exposure to potential toxic chemicals, while much less work has been done on the oral route of exposure. This is due in part to the difficulties of applying traditional oral toxicity testing to aquatic environments, including the tendency for test chemicals to dissolve into water. The use of biopolymer nanopartic...