Real-time parametric statistical analysis of functional MRI (fMRI) data would potentially enlarge the scope of experimentation and facilitate its application to clinical populations. A system is described that addresses the need for rapid analysis of fMRI data and lays the foundation for dealing with problems that impede the application of fMRI to clinical populations. The system, I/OWA (Input/...

Existing standard statistical procedures do not seem to fulfill the needs of the researcher in global quality-of-life (QOL) research, because the most interesting question seems to be the exact size of statistical covariations. A method is necessary if we are to isolate the most important factors connected to quality of life among the thousands of possible factors in life. We have developed a n...

This paper proposes a class of optimal design criteria for prediction in linear regression models with r responses based on the volume of the rectangular confidence region, termed RL-optimality. A general equivalence theorem and a geometrical characterization of the RL r -optimal design are established, which are used to obtain or verify the RL r optimality. Several examples are given for illus...

The Laboratory Standardization Panel of the National Cholesterol Education Program recommends that cholesterol method accuracy ideally be within 3% of the true value determined by the Abell-Kendall Reference Method, a component of the National Reference System for Cholesterol. As one of the Abell-Kendall network laboratories established to facilitate cholesterol standardization, the approach we...

This article describes the plreg Stata command, which implements the difference-based algorithm for estimating the partial linear regression models.

This paper illustrates negotiations around risk between lay people and clinicians in relation to gastrostomy interventions for disabled children. These negotiations centre on differing interpretations of what constitutes risk in relation to the safety of oral feeding and a child’s need for a feeding tube between parents, carers and clinical specialties. Drawing on Heyman’s distinction between r...

We explore some geometric aspects of compensation compactness associated to Jacobian determinants. We provide the optimal constant in Wente's inequality-the original motivation of this work-and go on to give various extensions to geometric situations. In fact we improve Wente's inequality somewhat, making it more appropriate for applications in which optimal results are required. This is demons...

In this paper, we study filtering of multiscale dynamical systems with model error arising from limitations in resolving the smaller scale processes. In particular, the analysis assumes the availability of continuous-time noisy observations of all components of the slow variables. Mathematically, this paper presents new results on higher order asymptotic expansion of the first two moments of a ...

The contrast gloss and the average roughness were measured for four commercial composite filling materials. Using a factorial design, each material was subjected to four available finishing methods. A significant difference was found in the contrast gloss among finishing methods, and a significant linear regression is given which relates the inverse of the contrast gloss to the average roughnes...

In developed nations, approximately half of household environments contain pets. Studies of Human-Animal Interaction (HAI) have proposed that there are health benefits and risks associated with pet ownership. However, accurately demonstrating and understanding these relationships first requires a better knowledge of factors associated with ownership of different pet types. A UK birth cohort, th...