نتایج جستجو برای: chemoresistance

تعداد نتایج: 5112  

2014
Xin Wang Xinyi Casuarine Low Weixin Hou Lissa Nurrul Abdullah Tan Boon Toh Masturah Mohd Abdul Rashid Dean Ho Edward Kai-Hua Chow

Chemoresistance is a primary cause of treatment failure in cancer and a common property of tumor-initiating cancer stem cells. Overcoming mechanisms of chemoresistance, particularly in cancer stem cells, can markedly enhance cancer therapy and prevent recurrence and metastasis. This study demonstrates that the delivery of Epirubicin by nanodiamonds is a highly effective nanomedicine-based appro...

Journal: :European review for medical and pharmacological sciences 2014
H-X Li Q-P Meng W Liu Y-G Li H-M Zhang F-C Bao L-L Song H-J Li

OBJECTIVE Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. Despite aggressive therapy, survival outcomes remain unsatisfactory, especially for patients with metastatic disease or patients with a poor chemotherapy response. Previous study founds inosine 5'-monophosphate dehydrogenase type II (IMPDH2) was an independent prognostic factor and observed...

Journal: :Cancer research 2015
Fu-Gui Ye Chuan-Gui Song Zhi-Gang Cao Chen Xia Dan-Na Chen Li Chen Shan Li Feng Qiao Hong Ling Ling Yao Xin Hu Zhi-Ming Shao

There has been little study of how the evolution of chemoresistance in cancer affects other aspects of disease pathogenesis. Here, we show that an important chemoresistance axis driven by cytidine deaminase (CDA) also acts to suppress cell-cycle progression by regulating cyclin E-CDK2 signaling. We found that CDA was regulated by miR-484 in a gemcitabine-resistant model of breast cancer. Elevat...

2016
Yong Xie De-Wu Zhong

Hypoxia is a common characteristic of hepatocellular carcinoma (HCC) associated with reduced response to chemotherapy, thus increasing the probability of tumor recurrence. Astrocyte elevated gene-1 (AEG-1) has been involved in a wide array of cancer progression including proliferation, chemoresistance, angiogenesis and metastasis, but its effect on HCC chemoresistance induced by hypoxia is uncl...

2017
Terumasa Sowa Toshi Menju Toyofumi F. Chen‐Yoshikawa Koji Takahashi Shigeto Nishikawa Takao Nakanishi Kei Shikuma Hideki Motoyama Kyoko Hijiya Akihiro Aoyama Toshihiko Sato Makoto Sonobe Hiroshi Harada Hiroshi Date

Lung cancer treatment is difficult owing to chemoresistance. Hypoxia-inducible factor 1 (HIF-1) and HIF-1-induced glycolysis are correlated with chemoresistance; however, this is not evident in lung cancer. We investigated the effect of HIF-1α and carbonic anhydrase IX (CAIX), a transmembrane protein neutralizing intracellular acidosis, on chemoresistance and prognosis of lung cancer patients a...

2017
Quan Cheng Xiaoqiang Ma Hui Cao Zigui Chen Xin Wan Rui Chen Renjun Peng Jun Huang Bing Jiang

Glioblastoma (GBM) is the predominant and most fatal type of brain tumor in adults. The prognosis of GBM remains poor despite advances in surgery, chemotherapy and radiotherapy. It is common that patients with GBM exhibit innate or acquired resistance to temozolomide (TMZ), a standard chemotherapeutic agent for GBM, and a previous report demonstrated that miRNA‑233 (miR‑223) promotes the growth...

Journal: :Blood 2010
Jose A Richter-Larrea Eloy F Robles Vicente Fresquet Elena Beltran Antonio J Rullan Xabier Agirre Maria José Calasanz Carlos Panizo Jose A Richter Jesus M Hernandez Jose Roman-Gomez Felipe Prosper Jose A Martinez-Climent

In Burkitt lymphoma/leukemia (BL), achievement of complete remission with first-line chemotherapy remains a challenging issue, as most patients who respond remain disease-free, whereas those refractory have few options of being rescued with salvage therapies. The mechanisms underlying BL chemoresistance and how it can be circumvented remain undetermined. We previously reported the frequent inac...

2014
Haoxuan Zheng Zhizhong Liu Tao Liu Yidong Cai Yadong Wang Shiyong Lin Jinmin Chen Jing Wang Zhiqing Wang Bo Jiang

Fas signaling promotes metastasis of gastrointestinal (GI) cancer cells by inducing epithelial-mesenchymal transition (EMT), and EMT acquisition has been found to cause cancer chemoresistance. Here, we demonstrated that the response to chemotherapy of GI cancer patients with higher expression of FasL was significantly worse than patients with lower expression. Fas-induced activation of the ERK1...

2017
Wei Jin Xiaodong Liao Yaping Lv Zhi Pang Yuming Wang Quanfu Li Yahui Liao Qing Ye Guoqiang Chen Kewen Zhao Lei Huang

Chemoresistance contributes to cancer relapse and increased mortality in a variety of cancer types, raising a pressing need to better understand the underlying mechanism. MUC1 is abnormally overexpressed in numerous carcinomas and associated with poor prognosis. However, the functional significance of MUC1 in chemoresistance has not been fully elucidated. Here, we showed that MUC1 expression wa...

2013
Lissa Nurrul Abdullah Edward Kai-Hua Chow

Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recurrence and ultimately death because of treatment failure. In recent years, cancer stem cells (CSCs) have gained intense interest as key tumor-initiating cells that may also play an integral...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید