The goal of cancer chemotherapy is to prevent or slow the growth tumors by using various Biological natural agents. Epidemiological and pre-clinical data indicate that phytochemicals can influence cell proliferation cycle regulation, are typically involved in multiple signaling pathways frequently disrupted during tumour initiation, proliferation, propagation, strengthen host immune system, mak...

Anthocyanins are polyphenolic ring-based flavonoids, and are widespread in fruits and vegetables of red-blue color. Epidemiological investigations and animal experiments have indicated that anthocyanins may contribute to cancer chemoprevention. The studies on the mechanism have been done recently at molecular level. This review summarizes current molecular bases for anthocyanidins on several ke...

Chemoprevention is a relatively novel and promising approach for controlling cancer that uses specific natural products or synthetic agents to suppress, reverse, or prevent premalignancy before transformation into invasive cancer. Oral cavity squamous cell carcinoma (OCSCC) represents a large, worldwide health burden with approximately 274,000 cases diagnosed annually worldwide. Smoking and alc...

Mammary gland cancer is a serious worldwide medical problem. Chemoprevention is rapidly growing area of oncology. The strategy of chemoprevention seems to be promising for reducing cancer incidence both in well-defined high-risk individuals and also in the general population. Based on mechanism of action, two classes of agents – selective oestrogen receptor modulators and retinoids – are effect...

Renewed interest is being directed toward chemoprevention as a means of reducing cancer mortality. To overcome the inherent problems associated with using cancer development as a study end point, there has recently been a great surge of interest in defining the biomarkers associated with specific stages of the carcinogenic process as intermediate end points. We have detailed the evidence suppor...