The effects of hypoxia (O2-free), aglycemia (glucose-free), ischemia (O2- and glucose-free) and chemical anoxia (by 3-nitropropionic acid; 3-NPA) were evaluated on the synaptic transmission in vitro. Stimulation of a dorsal root in hemisected spinal cord from neonatal rat, evoked monosynaptic (MSR) and polysynaptic reflexes (PSR) in the segmental ventral root. In all the hypoxic conditions, the...

conclusions trauma induced by the tip of the catheter at the contact location with the lv wall in a patient with mild hypercoagulable state accounted for intracardiac thrombosis formation and its embolization to the brain and intestines. introduction coronary angiography can be complicated by some major complications such as stroke. case presentation we describe a patient who presented with hem...

conclusions continuous portal triade clamping (the pringle maneuver) during liver ischemia (30 and 45 minutes) in rabbits resulted in no ischemic change. increasing time of clamping to 30 minutes was safe in intermittent pringle maneuver. materials and methods in an experimental study, 20 new-zealand white rabbits were selected. in laparotomy, a blunt dissector was passed through the foramen of...

background in contemporary practice, acute mesenteric ischemia (ami) remains a serious cause of morbidity and mortality in abdominal emergencies. objectives we report the measurement of peritoneal fluid potassium and ph on a small series of rats that developed extensive ami following the surgical ligation of superior mesenteric vessels and compare the results with control groups. materials and ...

Renal ischemia–reperfusion (IR) is inevitable in partial nephrectomy and kidney transplantation. Acute tubular necrosis (ATN) induced by renal IR causes the loss of functional units kidney, pathologically presenting as nonhomogeneous distribution normal uriniferous tubules usually used to characterize activity. Optical coherence tomography (OCT) has been proven have ability image microstructure...

HighlightsIntracellular renin and angiotensin disrupts chemical communication in heart.Epigenetic modification of renin angiotensin aldosterone system (RAAS) and heart disease.Intracrine renin angiotensin and metabolic cooperation.Gap junction, intracellular renin and angiotensin, cellular patterns, and heart development. The finding that intracellular renin and angiotensin II (Ang II) disrupts...

introduction: stroke is the third important reason of death in adults and an important cause of adult disability. previous studies suggest that tgf-alpha can induce neurogenesis after stroke. here in, we studied neurogenesis effects of the tgf-alpha on subventricular zone following ischemia-reperfusion. male wistar rats (250-300 g) were divided into ischemia and treatment groups. after inductio...

BACKGROUND The accumulation of intracellular sodium during myocardial ischemia couples an inappropriate calcium influx and depressed cardiac recovery during subsequent reperfusion. The effects of the selective sodium/ hydrogen exchange inhibitor HOE 694 are evaluated during myocardial ischemia and reperfusion. METHODS Ten isolated rat hearts were subjected to a 2-minute infusion of St. Thomas...

Direct evidence for substantial mobilization of copper in the coronary flow immediately following prolonged, but not short, cardiac ischemia is presented. In the first coronary flow fraction (CFF) of reperfusion (0.15 ml), after 35 min of ischemia, the level of copper (as well as of iron) was 8- to 9-fold higher than the preischemic value. The levels in subsequent CFFs decreased and reached the...

The signal transduction pathways that mediate activation of trans acting factors controlling an organ's response to ischemia are unknown. The stress-activated protein kinases (SAPKs), a subfamily of the extracellular signal-regulated kinases (ERKs), phosphorylate c-Jun within the amino-terminal transactivation domain and are activated in response to a variety of cellular stresses. We determined...