نتایج جستجو برای: chelator resistant
تعداد نتایج: 195912 فیلتر نتایج به سال:
The major function of human transferrin is to deliver iron from the bloodstream to actively dividing cells. Upon iron release, the protein changes its conformation from 'closed' to 'open'. Extensive studies in vitro indicate that iron release from transferrin is very complex and involves many factors, including pH, the chelator used, an anion effect, temperature, receptor binding and intra-lobe...
Abstract The aim of our work was to develop a generally applicable liquid chromatographic method for the determination residue free 68 Ga 3+ content labeling reaction mixtures, in order facilitate comparative experiments early stages chelator development. We achieved retention on mixed mode cation exchanger HPLC column with gradient program, which allowed separation from non-retained complexes....
Here, we report that ExSO3H, a synthetically accessible, water-soluble, non-toxic derivative of the clinical iron chelator deferasirox, acts as colorimetric chemosensor permits detection and quantification Fe3+ in aqueous samples at pH 2–5. In addition, observed fluorescent turn-on response was produced when this allowed to interact with human serum albumin (HSA). This fluorescence quenched pre...
Sickle erythrocytes have increased ferritin and increased molecular iron on the inner membrane leaflet, and we postulated that cytosolic labile iron is also elevated. We used the fluorescent metallosensor, calcein, and a permeant Fe2 chelator to estimate labile cytoslic Fe2 , and calcein plus an Fe3 chelator to estimate total cytosolic labile iron (Fe2 Fe3 ). We measured membrane nonheme iron b...
Abstract Dual functionalization of targeting vectors, such as peptides and antibodies, is still synthetically challenging despite the increasing demand for molecules serving multiple purposes (i.e., optical nuclear imaging). Our strategy was to synthesize a versatile building block via orthogonal incorporation chemical entities (e.g., radionuclide chelator, fluorescent dye, cytotoxic drugs, cli...
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