We hereby report a 79-year-old Iranian man presenting with nail dystrophy and subsequent development of purpuric and ecchymotic plaques, hemorrhagic bullae, and infiltrated papules on the head, neck and trunk. Histological examination of the gingiva, bone marrow aspiration, and biopsy confirmed the diagnosis of primary systemic amyloidosis. In this case, nail dystrophy was the presenting sign o...

Edema bullae typically forms at the site of skin swelling during acute states of volume overload, most commonly during renal or cardiac failure. Herpes zoster is a reactivation of latent varicella zoster virus that typically presents as painful vesicles in a dermatomal distribution. In immunocompromised individuals, disseminated herpes zoster skin manifestations may occur with several lesions i...

Figure 1. Clinical photograph of linear IgA bullous dermatosis showing tense bullae and erosions involving the lower abdomen, inner thighs, and extremities.

ABH: angina bullosa hemorrhagica H&E: hematoxylin-eosin INTRODUCTION Angina bullosa hemorrhagica (ABH) is a rare benign disorder characterized by sudden onset of painless, blood-filled, blisters of the oral cavity that quickly expand and rupture spontaneously within 24 to 48 hours. First reported in 1967, ABH has been noted under other diagnostic terms including recurrent or traumatic oral hemo...

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Since the research work of Fischer-Wasels by anatomic methods, we know that in the pathogenesis of so-called idiopathic spontaneous pneumothorax certain bullae, situated on the surface of the lung, play an important part. Later our concept was further extended by pleural endoscopy which made possible not only exact diagnosis, but also effective therapy. We learned by means of biopsy that the bu...