Increasing evidence shows that TIM-1 and TIM-3 in-fluence chronic autoimmune diseases, and their expression levels in immune cells from nephritic patients are still unknown. Real-time transcription-polymerase chain reaction analysis was used to deter-mine expression levels of TIM-1 and TIM-3 mRNA in peripheral blood mononuclear cells (PBMCs) from 36 patients with minimal change glo-merulopathy ...

this study develops and analyzes preconditioned krylov subspace methods to solve linear systemsarising from discretization of the time-independent space-fractional models. first, we apply shifted grunwald formulas to obtain a stable finite difference approximation to fractional advection-diffusion equations. then, we employee two preconditioned iterative methods, namely, the preconditioned gene...

CONTEXT Knowledge of family cancer history is important for assessing cancer risk and guiding screening recommendations. OBJECTIVE To quantify how often throughout adulthood clinically significant changes occur in cancer family history that would result in recommendations for earlier or intense screening. DESIGN AND SETTING Descriptive study examining baseline and follow-up family history d...

The endothelium, once thought of as a cellophane-like inner lining for blood vessels, is now known as a selective barrier between blood and the surrounding tissue. Endothelial cells (ECs) specialize their barrier function, as in brain ECs, where the blood–brain barrier protects neurons against toxins, or in liver ECs, where they are highly fenestrated for efficient filtering of the blood. Angio...

This paper reports on an experiment aimed at improving an automatically generated phonetic transcription of the Spoken Dutch Corpus (CGN). Different techniques are explored to improve an automatically generated phonetic transcription (AGT). The different AGTs are compared to a reference transcription to determine their quality. The results indicate that implementing phonological rules does impr...

We are facing the exhaustion of newly assignable IPv4 addresses. Unfortunately, IPv6 is not yet deployed widely enough to fully replace IPv4, and it is unrealistic to expect that this is going to change before we run out of IPv4 addresses. Letting hosts seamlessly communicate in an IPv4world without assigning a unique globally routable IPv4 address to each of them is a challenging problem, for ...

Infective endocarditis (IE) is associated with poor prognosis and higher mortality. IE‑induced glomerulonephritis, especially crescentic glomerulonephritis (IE‑CGN) with renal dysfunction, is an independent risk factor for mortality. For the treatment of IE‑CGN, many therapeutic strategies including antibiotics alone, antibiotics combined with corticosteroid, immunosuppressive agents, plasmaphe...

OBJECTIVES The purpose of this study was to evaluate the outcome of systemic lupus erythematosus (SLE) patients on continuous ambulatory peritoneal dialysis (CAPD). METHODS Eighteen SLE patients who had been undergoing CAPD for at least 3 months in our unit were compared with 36 other age- and gender-matched non-diabetic CAPD patients with an underlying primary chronic glomerulonephritis (CGn...

This paper reports on an experiment aimed at establishing how phonetic transcriptions for the large CGN corpus can be obtained most efficiently. This experiment explores the po­ tential of an automatically generated transcription (AGT) by comparing an AGT with a reference transcription (Tref) of the same material, to determine whether and how the AGT can be improved to make it more similar to T...

This paper first describes the aims of the prosodic annotation for (part of) the Spoken Dutch Corpus (Corpus Gesproken Nederlands, CGN), and the procedures that are currently being developed to produce the annotation. It further reports on a pilot study that was run to estimate the costs and the attainable quality (in terms of inter-transcriber consistency) of the envisaged annotation. It is ou...