نتایج جستجو برای: cetp

تعداد نتایج: 1082  

Journal: :Journal of lipid research 1999
K Saito K i Kobori H Hashimoto S Ito M Manabe S Yokoyama

Among the monoclonal antibodies (Mab) against rabbit plasma cholesteryl ester transfer protein (CETP), Mab 14-8F cross-reacted with human CETP and selectively inhibited triglyceride transfer but not cholesteryl ester transfer (Ko, K. W. S., T. Ohnishi, and S. Yokoyama. 1994. J. Biol. Chem. 269: 28206;-28213). The epitope of this antibody was studied by using synthetic fragment peptides of rabbi...

Journal: :Genetics and molecular research : GMR 2014
C J Zhang H M Qiu J P Qiu

To investigate the relationship of polymorphisms in the cholesteryl ester transport protein (CETP) gene with coronary heart disease (CHD) and diabetes in subjects of Uyghur and Han Chinese origin, 266 subjects with CHD including 154 subjects with type 2 diabetes mellitus and 136 healthy subjects (as a control group) were enrolled in this study. Polymerase chain reaction and an enzymatic assay b...

Journal: :The Journal of biological chemistry 2000
K Kawano S C Qin M Lin A R Tall X C Jiang

Plasma phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) are homologous molecules that mediate neutral lipid and phospholipid exchange between plasma lipoproteins. Biochemical experiments suggest that only CETP can transfer neutral lipids but that there could be overlap in the ability of PLTP and CETP to transfer or exchange phospholipids. Recently developed PLT...

Journal: :The Journal of biological chemistry 1992
L B Agellon P Zhang X C Jiang L Mendelsohn A R Tall

The plasma cholesteryl ester transfer protein (CETP), primarily synthesized in the liver of several species, is expressed at very low levels in a number of transformed human liver cell lines. The human CETP gene promoter contains a sequence that closely resembles the binding site for the transcription factor CCAAT/enhancer-binding protein (C/EBP). This site is capable of binding C/EBP, as shown...

Journal: :Acta biochimica et biophysica Sinica 2004
Ke-Qin Zheng Si-Zong Zhang Li Zhang De-Jia Huang Lin-Chuan Liao Yi-Ping Hou

Cholesteryl ester transfer protein (CETP) is a key participant in the reverse transport of cholesterol from the peripheral tissues to the liver. To understand further the role that CETP gene plays in the pathogenesis of coronary heart disease (CHD), the promoter region, all 16 exons and adjacent intronic regions of CETP gene were screened for single nucleotide polymorphisms (SNPs) in 203 CHD pa...

2017
Shoucui Gao Xiaojing Wang Daxing Cheng Jiayan Li Lu Li Linwu Ran Sihai Zhao Jianglin Fan Enqi Liu

High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels. However, many CETP inhibitors have failed to achieve a clinical benefit despite raising HDL-C...

Journal: :Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1996
G W Meijer J E Groener A C Beynen A Van Tol

We investigated the relationship between the development of hypercholesterolemia in rabbits and cholesteryl ester transfer protein (CETP) activity secretion by their perfused livers. Two inbred strains of rabbits were compared which differ markedly in their hypercholesterolemic response to dietary cholesterol. Feeding a high-cholesterol (0.3%) diet, increased plasma and liver cholesterol level ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2008
José W A van der Hoorn Willeke de Haan Jimmy F P Berbée Louis M Havekes J Wouter Jukema Patrick C N Rensen Hans M G Princen

OBJECTIVE Niacin potently decreases plasma triglycerides and LDL-cholesterol. In addition, niacin is the most potent HDL-cholesterol-increasing drug used in the clinic. In the present study, we aimed at elucidation of the mechanism underlying its HDL-raising effect. METHODS AND RESULTS In APOE*3Leiden transgenic mice expressing the human CETP transgene, niacin dose-dependently decreased plasm...

Journal: :Journal of lipid research 1997
H Chiba H Akita K Tsuchihashi S P Hui Y Takahashi H Fuda H Suzuki H Shibuya M Tsuji K Kobayashi

High density lipoprotein (HDL) with and without apolipoprotein (apo) E was quantified and characterized in subjects with three genotypes of cholesteryl ester transfer protein (CETP) deficiency: the nonsense mutation in intron 14 (10 homozygotes and 5 heterozygotes); the missense mutation in the exon 15 (3 homozygotes and 9 heterozygotes); and the Int14A/D442G in 6 compound heterozygotes. ApoE-p...

Journal: :Journal of lipid research 2004
Jean-Charles Hogue Benoît Lamarche Daniel Gaudet Mathieu Larivière André J Tremblay Jean Bergeron Isabelle Lemieux Jean-Pierre Després Claude Gagné Patrick Couture

Small, dense LDL particles have been associated with an increased risk of coronary artery disease, and cholesteryl ester transfer protein (CETP) has been suggested to play a role in LDL particle remodeling. We examined the relationship between LDL heterogeneity and plasma CETP mass in familial hypercholesterolemia (FH). LDL particles were characterized by polyacrylamide gradient gel electrophor...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید