Surwit—Treatment of Urge Incontinence Earl A. Surwit, MD, has been a clinical professor of obstetrics and gynecology at the University of Arizona, Tucson, since 1986. His focus is in the fields of urogynecology, pelvic floor medicine, nonsurgical management of urinary incontinence, and fecal incontinence and pelvic prolapse. Dr Surwit has been the recipient of numerous grants, including serving...

Blinded urinary assays for cyclic guanosine 3':5'-monophosphate (cGMP) and cyclic adenosine 3':5'-monophosphate (cAMP) were performed on 49 subjects with documented abnormal cervical cytology and 21 control subjects with normal cytology. A significant difference in the mean cGMP:cAMP ratios between the case and control groups was found. A significantly greater proportion of women with cytologic...

AIMS The prevalence of cervical cancer in a developing country, and diagnostic therapeutic value of knife conization for CIN, indications, cytopathologic results and complications of conization, were evaluated. METHODS This retrospective- descriptive study concerned 44 cases that underwent conization. RESULTS The age range of patients was 18-75 (mean=43), and parity ranges were from 0-10 (m...

AIMS Atypical immature metaplasia (AIM) refers to a full-thickness intraepithelial basaloid lesion in the uterine cervix that features both metaplasia and atypia and is therefore difficult to distinguish from high-grade cervical intraepithelial neoplasia (CIN III). p16 is a marker for human papillomavirus (HPV)-induced dysplasia. Cytokeratin (CK) 17 is a marker for cervical reserve (stem) cells...

Aims: Atypical immature metaplasia (AIM) refers to a full-thickness intraepithelial basaloid lesion in the uterine cervix that features both metaplasia and atypia and is therefore difficult to distinguish from high-grade cervical intraepithelial neoplasia (CIN III). p16 is a marker for human papillomavirus (HPV)-induced dysplasia. Cytokeratin (CK) 17 is a marker for cervical reserve (stem) cell...

High-risk human papillomaviruses (HPV) encode two oncogenes, E6 and E7, expressed in nearly all cervical cancers. In vivo , HPV-16 E7 has been shown to induce multiple phenotypes in the context of transgenic mice, including cervical cancer. E7 is a multifunctional protein known best for its ability to inactivate the tumor suppressor pRb. To determine the importance of pRb inactivation by E7 in ...

High-risk human papillomaviruses (HPV) encode two oncogenes, E6 and E7, expressed in nearly all cervical cancers. In vivo, HPV-16 E7 has been shown to induce multiple phenotypes in the context of transgenic mice, including cervical cancer. E7 is a multifunctional protein known best for its ability to inactivate the tumor suppressor pRb. To determine the importance of pRb inactivation by E7 in c...

This study evaluates the feasibility of handheld vital microscopy for noninvasive, objective assessment microcirculation human uterine cervix. We qualitatively and quantitatively describe in healthy subjects order to provide a basis its application cervical pathology. Incident dark field imaging was used image four quadrants ectocervix ten participants. If squamocolumnar junction visible, measu...

Human papillomavirus infection is the major cause of cancers of the cervix, vagina, and vulva (1). Nonmelanomatous skin cancers have been associated with human papillomavirus infection in patients with epidermodysplasia verruciformis and in patients who are immunosuppressed or nonimmunosuppressed, although the data are scant (1,2). We used the cancer registry of the Swiss Canton of Vaud (with a...

Telomere length shortening appears to be one of the earliest in the initiation of epithelial carcinogenesis. It may lead to further activation of the DNA damage cellular response pathways. For instance, telomere instability occurs in most cases of early and preinvasive stage of bladder, prostate, cervix, colon, esophageal, or breast cancer (1, 2). In our study (1), preneoplastic lesions (especi...