نتایج جستجو برای: ceruloplasmin
تعداد نتایج: 1812 فیلتر نتایج به سال:
The link between iron and Alzheimer's disease (AD) has been mainly investigated with a focus on the local accumulation of this metal in specific areas of the brain that are critical for AD. In the present study, we have instead looked at systemic variations of markers of iron metabolism. We measured serum levels of iron, ceruloplasmin, and transferrin and calculated the transferrin saturation a...
It was recently reported (Niedermeier, Creitz, and Holley, 1962) that the copper concentration in synovial fluid from patients with rheumatoid arthritis was elevated by a factor of three. The observation that copper could not be dialysed out of either "normal" or rheumatoid synovial fluid led to speculation concerning the nature of the compounds with which this element was associated. It was sh...
ceruloplasmin (cp) is a human plasma protein with multiple physiological functions including ferroxidase and oxidase activities. deficiency or inhibition of the enzyme may lead to some abnormalities, including iron deposition in several tissues and causes various pathological conditions in the body. direct interaction of cadmium (cd), a widespread, highly toxic environmental pollutant, with hum...
Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development
In the last 15 years, among many reasons given for development of idiopathic forms Parkinson’s disease (PD), copper imbalance has been identified as a factor, and PD is often referred to copper-mediated disorder. More than 640 papers have devoted relationship between status in blood, which include following markers: total concentration, enzymatic ceruloplasmin (Cp) Cp protein level, non-cerulop...
A method for the speciation of zinc and copper binding with proteins in human serum was explored by chelating resin (Chelex-100) pre-treatment and inductively coupled plasma mass spectrometry (ICP-MS). It was shown by a SEC (size-exclusion chromatography)-ICP-MS system that albumin-zinc and albumin-copper (loosely-bound species) could be selectively removed from serum by adsorption on the Chele...
Low copper and ceruloplasmin in serum are the diagnostic hallmarks for Menkes disease, Wilson disease, and aceruloplasminemia. We report on five patients from four unrelated families with these biochemical findings who presented with a lethal autosomal-recessive syndrome of congenital cataracts, hearing loss, and severe developmental delay. Cerebral MRI showed pronounced cerebellar hypoplasia a...
We describe a rapid nephelometric assay for measurement of ceruloplasmin in serum with the Multistat centrifugal analyzer. In establishing the optimum conditions, the concentration of polyethylene glycol was critical. With a 30 g/L solution of polyethylene glycol, the calibrators and samples react at the same rate, while with a 60/L solution the calibrators react faster than the samples. The re...
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