Tumor necrosis factor (TNF ) is an immunomodulatory and proinflammatory cytokine implicated in neuroinflammation and neuronal damage in response to cerebral ischemia. Tumor necrosis factorconverting enzyme (TACE or ADAM17) is a key sheddase that releases TNF from its inactive cell-bound precursor. Using a selective small molecule inhibitor of TACE, DPH-067517, we tested the hypothesis that inhi...
