نتایج جستجو برای: centrosome

تعداد نتایج: 4354  

2014
Jose Reina Cayetano Gonzalez

A strong correlation between centrosome age and fate has been reported in some stem cells and progenitors that divide asymmetrically. In some cases, such stereotyped centrosome behaviour is essential to endow stemness to only one of the two daughters, whereas in other cases causality is still uncertain. Here, we present the different cell types in which correlated centrosome age and fate has be...

2012
Min Gao Jannie Rendtlew Danielsen Lei-Zhen Wei Dong-Ping Zhou Qian Xu Miao-Miao Li Zhao-Qi Wang Wei-Min Tong Yun-Gui Yang

The maintenance of genomic stability requires accurate genome replication, repair of DNA damage, and the precise segregation of chromosomes in mitosis. GEN1 possesses Holliday junction resolvase activity in vitro and presumably functions in homology driven repair of DNA double strand breaks. However, little is currently known about the cellular functions of human GEN1. In the present study we d...

2012
Winnie W Y Lui-Roberts Jane C Stinchcombe Alex T Ritter Anna Akhmanova Iakowos Karakesisoglou Gillian M Griffiths

Cytotoxic T lymphocytes (CTLs) kill tumorigenic and virally infected cells by targeted secretion of lytic granule contents. The precise point at which secretion occurs is directed by the centrosome docking at the immunological synapse (IS). The centrosome is highly dynamic in CTLs, lagging behind the nucleus in the uropod of migrating CTLs, but translocating across the entire length of the cell...

Journal: :Current Biology 2008
Fei Zhu Steffen Lawo Alex Bird Deborah Pinchev Alison Ralph Constance Richter Thomas Müller-Reichert Ralf Kittler Anthony A. Hyman Laurence Pelletier

Centrosomes are the major microtubule-organizing centers of mammalian cells. They are composed of a centriole pair and surrounding microtubule-nucleating material termed pericentriolar material (PCM). Bipolar mitotic spindle assembly relies on two intertwined processes: centriole duplication and centrosome maturation. In the first process, the single interphase centrosome duplicates in a tightl...

Journal: :Journal of cell science 2007
Ryoko Kuriyama Yasuhiko Terada Kyung S Lee Christopher L C Wang

Centrosome duplication is tightly coupled with the cell cycle and neither too many nor too few centrosomes are induced in a normal cell. To study how centrosome assembly is regulated, we analyzed the abnormal process of multiple centrosome replications in Chinese hamster ovary (CHO) cells induced by hydroxyurea (HU), which is known to uncouple the centrosome cycle from the cell cycle. Green flu...

2016
Emilie Pallesi-Pocachard Elsa Bazellieres Annelise Viallat-Lieutaud Marie-Hélène Delgrossi Magali Barthelemy-Requin André Le Bivic Dominique Massey-Harroche

Polarity protein complexes function during polarized cell migration and a subset of these proteins localizes to the reoriented centrosome during this process. Despite these observations, the mechanisms behind the recruitment of these polarity complexes such as the aPKC/PAR6α complex to the centrosome are not well understood. Here we identify Hook2 as an interactor for the aPKC/PAR6α complex tha...

Journal: :Current Biology 2003
U. S. Tulu N. M. Rusan P. Wadsworth

In centrosome-containing cells, microtubules utilized in spindle formation are thought to be nucleated at the centrosome. However, spindle formation can proceed following experimental destruction of centrosomes or in cells lacking centrosomes, suggesting that non-centrosome-associated microtubules may contribute to spindle formation, at least when centrosomes are absent. Direct observation of p...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2015
Julieta Martino Amie L Holmes Hong Xie Sandra S Wise John Pierce Wise

Particulate hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen. Lung tumors are characterized by structural and numerical chromosome instability. Centrosome amplification is a phenotype commonly found in solid tumors, including lung tumors, which strongly correlates with chromosome instability. Human lung cells exposed to Cr(VI) exhibit centrosome amplification but the und...

Journal: :Current Biology 2010
Paul T. Conduit Kathrin Brunk Jeroen Dobbelaere Carly I. Dix Eliana P. Lucas Jordan W. Raff

BACKGROUND centrosomes are major microtubule organizing centers in animal cells, and they comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Centrosome size is tightly regulated during the cell cycle, and it has recently been shown that the two centrosomes in certain stem cells are often asymmetric in size. There is compelling evidence that centrioles influe...

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