Proteins control many vital functions in living cells, such as cell growth and division. Reliable coordination of these requires the spatial temporal organization proteins inside which encodes information about cell’s geometry cell-cycle stage. The study protein patterns has long focused around formation uniform environments. However, recent years, it become evident that heterogeneities are ess...

Studies of protein structure and dynamics are usually carried out in dilute buffer solutions, conditions that differ significantly from the crowded environment cell. The double electron-electron resonance (DEER) technique can track proteins’ conformations cell by providing distance distributions between two attached spin labels. This technique, however, cannot access distances below 1.8 nm. Her...

Background: Salinity is a major environmental limiting factor, which affect agricultural production. The two Manilkara seedlings (M. roxburghiana and M. zapota) with high economic importance, could not adapt well to higher soil salinity and little is known about their proteomic mechanisms. Objectives: The mechanisms responsible ...

Abstract Aims Improvements in the treatments for childhood and adolescent brain tumours, High-Grade Glioma (pHGG) Diffuse Intrinsic Pontine Glioblastoma (DIPG), have not advanced much they continue to carry a very poor prognosis. These tumours are now defined by mutations affecting histone 3 proteins, indeed 80% of DIPGs harbour H3.1 H3.3 K27M somatic whilst 30% pHGGs exhibit G34R or G34V mutat...

background: candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. it is speculated that structural and secretory proteins of c. albicans have immunomodulatory effects in cancer. objective: to evaluate the effects of c. albicans structural and secreted proteins on intratumoral cd4/cd8 ratio as well as the survival rate in balb/c t...

Objective(s): Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer metastasis. Here we have investigated the effect of a standardized Cannabis sativa extract on cell migration and Tau and Stathmin gene expression in the melanoma cell line. Materials an...

Background: Hepatitis C virus (HCV) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (HCC). Vaccination based on HCV capsid proteins has attracted a special interest for prevention of viral infections. The core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...