A two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (DCN) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. This conductance based model is a reduced version of KM-LIF model (Meng & Rinzel, 2010) which captures qualitative firing features of a...

gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...

DNA is organized into chromatin, a complex polymeric material that stores information and controls gene expression. An emerging mechanism for biological organization, particularly within the crowded nucleus, biomolecular phase separation condensed droplets of protein nucleic acids. However, way in which chromatin impacts dynamics condensate formation poorly understood. Here we utilize powerful ...

purpose: to present a patient with localized corneal edema due to a small retained fragment of nucleus in the anterior chamber after uncomplicated phacoemulsification. case report: a 74-year-old female subject with history of phacoemulsification in her right eye about 1.5 years ago complained of foreign body sensation, pain and decreased vision in the same eye. visual acuity of that eye had dec...

We investigated the mechanotransduction pathway in endothelial cells between their nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations in response to alterations of cell shape as cells detach from a flat surface. We found that the nuclear deformation appeared to be in direct and immediate response to alterations of the cell adhesion area. The nucleus was t...

this study has examined the functional importance of nucleus accumbens (nac)-ventral tegmental area (vta) interactions. as it is known, this interaction is important in associative reward processes. under urethane anesthesia, extracellular single unit recordings of the shell sub-region of the nucleus accumbens (nacsh) neurons were employed to determine the functional contributions of the vta to...

Background: Portulaca oleracea as a herbal plant has been widely used in traditional medicine to cure many diseases. The therapeutic effects of this plant are exerted through its active ingredients with antioxidant properties. It has been shown that this plant may have cytotoxic effects on cancer cells. In the present study, cytotoxic effects of aqueous extract of Portulaca oleracea on oral cav...

Plant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors play critical roles in mediating host immunity to pathogen attack. We use tomato Sw-5b::tospovirus as a model system study the specific role of compartmentalized plant NLR dictating defenses against virus at different infection steps. demonstrated here that Sw-5b distributes cytoplasm and nucleus, respectively, inducing ...

a two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (dcn) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. this conductance based model is a reduced version of km-lif model (meng & rinzel, 2010) which captures qualitative firing features of a...