In an area of lymphoma classification still being defined, marginal-zone lymphomas have distinctive immunohistochemical and cytogenetic features that distinguish them from mantle-cell and follicular lymphomas. There are three subtypes: the extranodal mucosa-associated lymphoid tissue (MALT) lymphomas, the nodal monocytoid B-cell (MBCL) lymphomas, and the splenic marginal-zone lymphomas. The MAL...

Most human lymphomas were consistent. Only few patients suffered two or more different types of lymphomas. We presented a case of discordant lymphomas composing simultaneous gastric diffuse large B-cell lymphoma and mixed cellularity Hodgkin lymphoma in stomach in a 50 y old male patient. The two lymphomas were clone-related lesions and with the same precursor cell, but they had their own typic...

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New insights from genomic studies have had an impact on the definition and diagnosis of several lymphoid tumors including follicular B-cell lymphomas, aggressive diffuse large lymphoproliferations associated with acquired posttransplant immunodeficiencies. Follicular lymphoma (FL) includes whose behavior varies widely indolent/early lesions to aggressive/transformed lymphomas. Although some lym...

An immunological characterization of leukemias and lymphomas was made in the rat by using a panel of membrane markers in combination with morphological analysis. In the present study, five antigen markers and three surface markers were used for the characterization of 20 rat leukemias and lymphomas, and it was indicated that they could be divided into at least six groups. Of the lymphomas studi...

T-cell lymphomas expressing the T-cell receptor (TCR) are uncommon, although their frequency may be underestimated. They show a broad clinicopathological spectrum. Besides precursor T-cell lymphoblastic leukemia/ lymphoma, various post-thymic T-cell neoplasms have been recognized. Among these, hepatosplenic T-cell lymphoma constitutes the prototype of T-cell lymphomas expressing the TCR and was...

BACKGROUND Mature T-cell and natural killer (NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas, and extranodal NK/T-cell lymphoma, nasal type (ENKTL) is an aggressive subtype with sporadic CD30 expression. However, the significance of CD30 expression in ENKTL is controversial. We aimed to classify a large cohort of patients with mature T-cell and NK-cell lymphomas accord...

BACKGROUND In our recent study, we determined the cut-off value of CD20 expression at the level of 25, 000 molecules of equivalent soluble fluorochrome (MESF) to be the predictor of response to rituximab containing treatment in patients with B-cell lymphomas. In 17.5% of patients, who had the level of CD20 expression below the cut-off value, the response to rituximab containing treatment was si...

Centrocytic lymphomas are defined in the Kiel classification as B-cell lymphomas composed exclusively of cells resembling cleaved follicular center cells (FCC). These lymphomas have been shown to be histologically, immunophenotypically, and clinically distinct from other cleaved FCC lymphomas. DNA from 18 centrocytic lymphomas (14 patients) was analyzed using Southern blotting and probes for im...