Alphavbeta3 is a key integrin mediating adhesion of multinucleated osteoclasts during bone resorption. 1, 25-dihydroxyvitamin D3 upregulates alphavbeta3 integrin expression in mononucleated osteoclast precursors and concomitantly stimulates their differentiation into osteoclasts. This suggests that this integrin could play a major role during osteoclast differentiation. We have developed an in ...

Platelets clump together by two different processes: agglutination and aggregation. Agglutination is a passive process, independent of the metabolic status of the platelets. It is a physical phenomenon of binding of a protein or glycoprotein, which has two or more binding domains. In contrast, platelet aggregation is a metabolically active, transmembrane process that requires “live” platelets. ...

Thrombosis, especially arterial, develops by mediation of platelets, adhering to collagen fibers at areas of endothelial cell damage. At this phase, platelet activation leads them to secrete factors [ADP, Fibrinogen, von Willebrand Factor (vWF), Fibronectin, Factor XIII] capable of promoting cell aggregation/adhesion and coagulation, inducing vasoconstriction (thromboxane A2) and acting as mito...

We consider here a recently developed upwind-difference potentials method for chemotaxis models [8]. The introduced scheme can be used to approximate problems in complex geometries. The chemotaxis model under consideration is described by a system of two nonlinear PDEs: a convection-diffusion equation for the cell density coupled with a reactiondiffusion equation for the chemoattractant concent...

We have studied the effects of two human pancreatic cancer and two human small cell lung cancer cell lines on clotting and platelet aggrega tion. Both pancreatic lines markedly shortened recalcification times and induced platelet aggregation. The lung cancer lines produced little short ening of recalcification times and no platelet aggregation. The clotting and aggregation activities of the pan...

Tyrosine hydroxylase (TH) is transiently detectable in cells distributed throughout cranial sensory ganglia during early stages of gangliogenesis [embryonic day (E) 10.5-15.5]. Although TH cells appear in embryonic ganglia of both neural crest and placode origin, mature cranial sensory neurons that express catecholaminergic properties are restricted to placode derivatives. The mechanism(s) unde...

introduction the continuous and rapid growth of telecommunication industries, along with the common application of cell phones, hasraised debates on the associated risks for humanhealth due to exposure to radiofrequency fields, caused bycell phonesorother sources, and industrial and medical applications. accordingly, in this study, we aimed to investigate the effects of cell phone radiation on ...

This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer (EC) among the Kazakh ethnic group in Xinjiang. CYP1A1 and GSTM1 gene polymorphisms were detected using peripheral blood from 86 subjects belonging to families with EC and 82 control subjects. Additionally, a questionnaire survey was condu...

Aggregation is an important concern for therapeutic antibodies, since it can lead to reduced bioactivity and increase the risk of immunogenicity. In our analysis of immunoglobulin G (IgG) molecules of identical amino acid sequence but produced either in mammalian cells (HEK293) or in the yeast Pichia pastoris (PP), dramatic differences in their aggregation susceptibilities were encountered. The...

The normal transmyocardial tissue hematocrit distribution (i.e., subepicardial greater than subendocardial) is known to be affected by red blood cell (RBC) aggregation. Prior studies employing the use of infused large macromolecules to increase erythrocyte aggregation are complicated by both increased plasma viscosity and dilution of plasma. Using a new technique to specifically alter the aggre...