Some years before thin sectioning techniques were developed, a number of investigators, notably Porter and his associates (6-8), made some new and interesting observations on cell structure by examining in the electron microscope fixed and dried preparations of whole cells grown on form-vat-coated glass surfaces. The method depends on the fact that the peripheral regions of such cells are often...

w ED1 + lmacmphages, monocytes and dendritic cellsl and ED2+ cells ImacrophaQoa ordvl agpear to have a role in comeal rejection followinp pen&ti~ kerato&~~ in the rat. In the fdlowinp presentation the distribution of ED1 and ED2 wsitive cdls in normal weal tissues of Lewis rats, the influence of comeal transpiantation and the efIeci of Cwlnspuin A lCsAl upon both types of wllr was examined. m 6...

w ED1 + lmacmphages, monocytes and dendritic cellsl and ED2+ cells ImacrophaQoa ordvl agpear to have a role in comeal rejection followinp pen&ti~ kerato&~~ in the rat. In the fdlowinp presentation the distribution of ED1 and ED2 wsitive cdls in normal weal tissues of Lewis rats, the influence of comeal transpiantation and the efIeci of Cwlnspuin A lCsAl upon both types of wllr was examined. m 6...

Presented is the metadata research and development in China. Beginning in the 1980s, the research project aimed at developing Chinese metadata standards, schemes, and specifications was first launched in 1997. Since then, many metadata-related projects have been conducted and completed. This paper summarizes the achievements of these projects, and introduces Chinese metadata standards, schemes,...

Cohesin complexes have been extensively studied for their roles in sister chromatid cohesion during cell division, and in addition, regulate transcription throughmultiple mechanisms. Together with Nipped-B, a cohesin-loading factor that facilitates enhancer-promoter interactions, cohesins bind many activated enhancers but seem to preferentially associate with a subset of active genes linked to ...

N 'atural Killer (NK) cells are cytotoxic lymphocytes that, in the absence of prior stimulation, lyse a variety of target cells, including tumor cells, virus-, or intracdlular bacteria-infected cells, and, in some cases, normal cells (1). Thus, NK cells represent a first line of defense to infections, tumor growth, or other pathogenic alterations of tissue homeostasis. Unlike T or B lymphocytes...

Specific cytotoxic T lymphocytes (CTL) against HLA antigens of skin fibroblasts were generated with mixed leukocyte culture (MLC). Nonspecific cytotoxicity (CTX) in 3H-proline microcytotoxicity test was detected as early as the 4th day by primary in vitro sensitization (IVS), and the activity continued until around the 8th day. The specific CTX by primary IVS was detectable from the 7th day to ...

| Advocacy organizations for genetic diseases are increasingly becoming involved in biomedical research, particularly translational research, in order to meet the needs of the individuals that they serve. PXE International, an advocacy organization for the disease pseudoxanthoma elasticum, provides an example of how research can be accelerated by these groups. It has adopted methods that were p...

Background: An emerging literature on behavioural phenotypes has highlighted apparent associations between autism spectrum disorders (ASDs) or ASD related phenomenology and a number of different genetically determined syndromes. Method: A systematic review of the current literature regarding the association with ASD and ASD characteristics was conducted in the following syndrome groups: Fragile...