نتایج جستجو برای: cdkl5

تعداد نتایج: 205  

2012
Jeffrey L. Neul

Rett syndrome (RTT, MIM #312750) is a neurodevelopmental disorder defined by a distinct set of clinical features, notably a regression that robs the affected individuals of spoken language and volitional hand use [1]. Additionally, affected people develop characteristic hand stereotypies that are classically wringing or washing in nature, although they make take on a variety of forms such as cl...

Journal: :Human mutation 2009
Periklis Makrythanasis Philipp Kapranov Lucia Bartoloni Alexandre Reymond Samuel Deutsch Roderic Guigó France Denoeud Jorg Drenkow Colette Rossier Francesca Ariani Valeria Capra Laurent Excoffier Alessandra Renieri Thomas R Gingeras Stylianos E Antonarakis

The study of transcription using genomic tiling arrays has lead to the identification of numerous additional exons. One example is the MECP2 gene on the X chromosome; using 5'RACE and RT-PCR in human tissues and cell lines, we have found more than 70 novel exons (RACEfrags) connecting to at least one annotated exon.. We sequenced all MECP2-connected exons and flanking sequences in 3 groups: 46 ...

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