نتایج جستجو برای: cdc42

تعداد نتایج: 3729  

Journal: :Current Biology 1998
Cheryl L. Neudauer Gérard Joberty Nia Tatsis Ian G. Macara

BACKGROUND Rho-family GTPases have central roles in cytoskeletal organization, proliferation, differentiation and apoptosis. Multiple factors possessing overlapping specificities for Rho GTPases have been identified. The Rho GTPases Cdc42 and Rac share many regulators and effectors, yet produce different phenotypes when expressed as gain-of-function mutants in cells. The Rho-family member TC10 ...

Journal: :Cell 2003
Zhong Li Michael Hannigan Zhicheng Mo Bo Liu Wei Lu Yue Wu Alan V. Smrcka Guanqing Wu Lin Li Mingyao Liu Chi-Kuang Huang Dianqing Wu

* move toward higher concentrations of chemoattractants. Summary Cdc42 has been shown to interact with and/or activate proteins known to be involved in cytoskeleton reorgani-Efficient chemotaxis requires directional sensing and zation, including the PAK kinases and Wiscott Aldrich cell polarization. We describe a signaling mechanism syndrome protein (WASP) (Schmidt and Hall, 1998; Bo-involving ...

Journal: :Eukaryotic cell 2004
Alysia L VandenBerg Ashraf S Ibrahim John E Edwards Kurt A Toenjes Douglas I Johnson

The yeast Candida albicans is a major opportunistic pathogen of immunocompromised individuals. It can grow in several distinct morphological states, including budded and hyphal forms, and the ability to make the dynamic transition between these forms is strongly correlated with virulence. Recent studies implicating the Cdc42p GTPase in hypha formation relied on cdc42 mutations that affected the...

2017
Yu ZHANG Qiao-Chu WANG Jun LIU Bo XIONG Xiang-Shun CUI Nam-Hyung KIM Shao-Chen SUN

The mammalian oocyte undergoes an asymmetric division during meiotic maturation, producing a small polar body and a haploid gamete. This process involves the dynamics of actin filaments, and the guanosine triphosphatase (GTPase) protein superfamily is a major regulator of actin assembly. In the present study, the small GTPase CDC42 was shown to participate in the meiotic maturation of porcine o...

2017
Yu Zhang Qiao-Chu Wang Jun Liu Bo Xiong Xiang-Shun Cui Nam-Hyung Kim Shao-Chen Sun

23 The mammalian oocyte undergoes an asymmetric division during meiotic maturation, 24 producing a small polar body and a haploid gamete. This process involves the dynamics of 25 actin filaments, and the guanosine triphosphatase (GTPase) protein superfamily is a major 26 2 regulator of actin assembly. In the present study, the small GTPase CDC42 was shown to 1 participate in the meiotic maturat...

Journal: :Development 2013
Kei-ichi Katayama Fumiyasu Imai Kenneth Campbell Richard A Lang Yi Zheng Yutaka Yoshida

Cortical interneurons arise from the ganglionic eminences in the ventral telencephalon and migrate tangentially to the cortex. Although RhoA and Cdc42, members of the Rho family of small GTPases, have been implicated in regulating neuronal migration, their respective roles in the tangential migration of cortical interneurons remain unknown. Here we show that loss of RhoA and Cdc42 in the ventri...

Journal: :Cancer research 2008
Chiara Ambrogio Claudia Voena Andrea D Manazza Cinzia Martinengo Carlotta Costa Tomas Kirchhausen Emilio Hirsch Giorgio Inghirami Roberto Chiarle

Anaplastic large cell lymphoma (ALCL) is a non-Hodgkin's lymphoma that originates from T cells and frequently expresses oncogenic fusion proteins derived from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK) gene. The proliferation and survival of ALCL cells are determined by the ALK activity. Here we show that the kinase activity of the nucleophosmin (NPM)-ALK f...

Journal: :Journal of cell science 2015
Mid Eum Lee Wing-Cheong Lo Kristi E Miller Ching-Shan Chou Hay-Oak Park

Cdc42 plays a central role in establishing polarity in yeast and animals, yet how polarization of Cdc42 is achieved in response to spatial cues is poorly understood. Using live-cell imaging, we found distinct dynamics of Cdc42 polarization in haploid budding yeast in correlation with two temporal steps of the G1 phase. The position at which the Cdc42-GTP cluster develops changes rapidly around ...

2015
Federico Iseppon Luisa M. R. Napolitano Vincent Torre Dan Cojoc

Small RhoGTPases, such as Cdc42 and RhoA, are key players in integrating external cues and intracellular signaling pathways that regulate growth cone (GC) motility. Indeed, Cdc42 is involved in actin polymerization and filopodia formation, whereas RhoA induces GC collapse and neurite retraction through actomyosin contraction. In this study we employed Förster Resonance Energy Transfer (FRET) mi...

Journal: :The Journal of Cell Biology 2005
Ji-Long Chen Raymond V. Fucini Lynne Lacomis Hediye Erdjument-Bromage Paul Tempst Mark Stamnes

Cytoskeletal dynamics at the Golgi apparatus are regulated in part through a binding interaction between the Golgi-vesicle coat protein, coatomer, and the regulatory GTP-binding protein Cdc42 (Wu, W.J., J.W. Erickson, R. Lin, and R.A. Cerione. 2000. Nature. 405:800-804; Fucini, R.V., J.L. Chen, C. Sharma, M.M. Kessels, and M. Stamnes. 2002. Mol. Biol. Cell. 13:621-631). The precise role of this...

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