The regulation of TNF inhibitor therapy-associated immune responses in inflammatory bowel diseases (IBD) children remains an urgent problem. study aimed at analyzing the expression CD39/CD73 endonucleotidases by different subsets peripheral blood T cells with IBD including Crohn's disease (n = 34) and ulcerative colitis 33) having received inhibitors comparison conditionally healthy 45). Lympho...

It is unclear whether ongoing CD4 monitoring is needed following immunologic and virologic response to antiretroviral therapy (ART). We investigated the proportion of clients who achieved a virologic and immunologic response and then had a subsequent CD4 count <200 cells/μL despite continued virologic suppression. Included in this analysis were clients receiving ART through the Rakai Health Sci...

Multiple sclerosis (MS) is a complex neurological disease and its prevalence is about 2 million in the world. Neuroinflammation plays a key role in MS. Vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of T-helper cell. Vitamin D is a micronutrient that is effective on immune function. Deficiently of Vitamin D is a ...

Background: Thermal burn injuries impair the host defence system. Hence, in the present study, we aimed at investigating the changes in the number and phenotype of peripheral blood lymphocyte populations (T, B, and natural killer cells) and their subpopulations in patients with thermal burns and determining the relationships with different sizes of total body surface area (TBSA). &nbsp;&nbsp; ...

Background: Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in regulation of the immune responses and suppression of anti-tumor defense. PD-1/B7-H1-blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells and also increase mortality of tumor cells; however their use is accompanied by adverse effects in pat...

We generated 1,090 ATAC-seq and 1,057 T-cell RNA-seq libraries from 153 subjects, derived 8 flow-sorted subsets (defined by CD4/CD8, CLA+/ CLA-, 0/24h CD3/CD28 stimulation). Effects of activation skin-homing were analyzed DESeq2. After peak calling, 78,234 consensus peaks present in ≥ 30 libraries. A Wald test examining simple main effects identified 9,072, 3,934, 21,174 as differentially acces...

in this paper, the multistage variational iteration method is implemented to solve a general form of the system of first-order differential equations. the convergence of the proposed method is given. to illustrate the proposed method, it is applied to a model for hiv infection of cd4+ t cells and the numerical results are compared with those of a recently proposed method.