OBJECTIVES The aim of this study was to evaluate the expression of MIB-1, BCL-2, VEGFR3, and CD31 and their associations with long-term survival in patients with renal cell cancer (RCC). PATIENTS AND METHODS This study consisted of 224 RCC patients who underwent radical nephrectomy from 1985 to 1995. Follow-up continued for up to over 20 years. MIB-1 and BCL-2 expression were analyzed alone, ...

We aimed to determine if chronic endurance-exercise habits affected redox status and paracrine function of CD34(+) and CD34(-)/CD31(+) circulating angiogenic cells (CACs). Subjects were healthy, nonsmoking men and women aged 18-35 yr and categorized by chronic physical activity habits. Blood was drawn from each subject for isolation and culture of CD34(+) and CD34(-)/CD31(+) CACs. No difference...

BACKGROUND Astrogliomas are the most common primary brain tumor. Its progression is the result of activation of oncogenes, inactivation of tumor suppressor genes (TSGs), and expression of various growth factors. The angiogenesis and p53 in astrogliomas play an important role in its grading, treatment strategies, and hence its clinical outcome. OBJECTIVES To analyze the frequency of presentati...

Liver cancer is an aggressive disease with a poor outcome. Here, we implicate the roles of arsenic trioxide (As2O3) and Ginsenoside Rg3 (GRg3) in VX2 carcinoma model of rabbits through CD31 and vascular endothelial growth factor (VEGF). Rabbits VX2 liver cancer models were established, then 24 rabbits were randomly divided into 3 groups with the same number (As2O3, GRg3 and control). Liver func...

BACKGROUND/AIM Both free alpha-galactosylceramide (αGalCer) and αGalCer-loaded dendritic cells (DCG) activate invariant natural killer T (iNKT) cells to varying degrees, with αGalCer inducing liver injury. We sought to evaluate liver injury by these two pathways. MATERIALS AND METHODS Mice were injected with αGalCer or DCG followed by analysis of serum alanine transaminase (ALT) activity leve...

26 We aimed to determine if chronic endurance exercise habits affected redox status and 27 paracrine function of CD34+ and CD34-/CD31+ circulating angiogenic cells (CACs). Subjects 28 were healthy, nonsmoking, men and women aged 18-35 yrs and categorized by chronic physical 29 activity habits. Blood was drawn from each subject for isolation and culture of CD34+ and 30 CD34-/CD31+ CACs. No diffe...

Heart failure remains a leading cause of morbidity and mortality. The cellular mechanism underlying the development of cardiac dysfunction is a decrease in the number of viable cardiomyocytes. Recent observations have suggested that the adult heart may contain a progenitor cell population. Side population (SP) cells, characterized by a distinct Hoechst dye efflux pattern, have been shown to exi...