Human T-cell leukemia virus type 1 infection makes CD4+ T cells transformed into leukemic cells, whereas human immunodeficiency virus make them destroyed. Interestingly, activation of CD30 led to the induction of apoptotic death of anaplastic large cell lymphoma cells, while Hodgkin’s lymphoma cells, which constitutively express NF-κB, were not susceptible to CD30-induced apoptosis. Such a plei...

Initiation of T lymphocyte responses to most Ags requires concurrent stimulation through the TCR and costimulatory receptors such as CD28. Following initial activation, secondary receptors are up-regulated that can costimulate T cells in concert with TCR engagement. One such receptor is the TNFR family member CD30. In this study, we report that unlike CD28, ligation of CD30 on normal effector T...

Levels of soluble CD30 (sCD30) in serum were elevated in patients with Plasmodium falciparum malaria but showed decline following treatment. The levels of sCD30 in serum were correlated significantly with the expression of gamma interferon by peripheral T cells. These data suggest that CD30(+) cells are upregulated during a malaria attack and that they may play a regulating role at the site of ...

keratoacanthoma (ka) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics  squamous cell carcinoma (scc). essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive scc. the clinical behavior of ka is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanth...

We report a case of primary cutaneous CD30+ post-transplant lymphoproliferative disorder with an uncommon finding of signet ring cell features in a heart transplant patient. The neoplastic cells were CD4 and CD30 positive, and negative for S-100, pancytokeratin, myeloperoxidase, and CD56. In situ hybridization for Epstein Barr Virus (EBV) was negative, even though the patient did have EBV viremia.

SLFN11 expressing tumor cells respond well to DNA-targeting anti-tumor reagents, as for its role in a dominant determination of sensitivity DNA damage responses. However, the roles patients with cutaneous T-cell lymphoma (CTCL) remain poorly understood. The aim this study is clarify expression profile major type CTCL, mycosis fungoides (MF) and Sezary syndrome (SS). Immunohistochemical showed t...

BACKGROUND Hodgkin's lymphoma and anaplastic large-cell lymphoma are the two most common tumors expressing CD30. Previous attempts to target the CD30 antigen with monoclonal-based therapies have shown minimal activity. To enhance the antitumor activity of CD30-directed therapy, the antitubulin agent monomethyl auristatin E (MMAE) was attached to a CD30-specific monoclonal antibody by an enzyme-...

the cd30 antigen seems to play a costimulatory role in maintaining the physiological balance between t-helper (th)1/th2 immune responses. in this study, plasma and in vitro soluble cd30 (scd30) secretion was investigated in patients with coronary artery disease (cad) as a plausible marker of dysregulated immune response. twenty one patients with angiographically confirmed cad and 31 healthy con...

tion of Karpas 299 cells with immobilized antibodies to CD30 was found to potently induce cell death, whereas in the same experiment the addition of these antibodies in their soluble form did not induce cell death and actually slightly enhanced viability (Figure 1). Also noteworthy is the fact that, in the earlier report by Gruss et al4 in which the cytotoxic effects of M44 and M67 were origina...

The t(2;5) (p23;q35) chromosomal translocation has been found in a high proportion of lymph node-based CD30+ large cell lymphomas of T-cell lineage. This translocation is believed to result in the expression of a fusion protein containing the catalytic domain of anaplastic lymphoma kinase (ALK) under the control of the promoter for nucleophosmin, a nucleolar phosphoprotein. Expression of ALK ac...