نتایج جستجو برای: cd24

تعداد نتایج: 1338  

Journal: :BMC Urology 2006
M Schostak H Krause K Miller M Schrader S Weikert F Christoph C Kempkensteffen J Kollermann

BACKGROUND Gene expression profiling has recently shown that the mRNA for CD24 is overexpressed in prostate carcinomas (Pca) compared to benign or normal prostate epithelial tissues. Immunohistochemical studies have reported the usefulness of anti-CD24 for detecting prostate cancer over the full range of prostate specimens encountered in surgical pathology, e.g. needle biopsies, transurethral r...

2012
Nadire Duru Ming Fan Demet Candas Cheikh Menaa Hsin-Chen Liu Danupon Nantajit Yunfei Wen Kai Xiao Angela Eldridge Brett A. Chromy Shiyong Li Douglas R. Spitz Kit S. Lam Max S. Wicha Jian Jian Li

Purpose:Tounderstand the role ofHER2-associated signalingnetwork inbreast cancer stemcells (BCSC) using radioresistant breast cancer cells and clinical recurrent breast cancers to evaluate HER2-targeted therapy as a tumor eliminating strategy for recurrent HER2 /low breast cancers. Experimental Design: HER2-expressing BCSCs (HER2þ/CD44þ/CD24 ) were isolated from radiation-treated breast cancer ...

Journal: :Molecular cancer therapeutics 2015
Yoshihiro Joshua Ono Akiko Tanabe Tomohito Tanaka Yoshimichi Tanaka Masami Hayashi Yoshito Terai Masahide Ohmichi

Endometrial cancer is the most prevalent gynecologic cancer in the Western world, and the number of advanced chemotherapy-resistant cancers is increasing with the absolute increase in patients. The development of resistance to chemotherapeutic drugs by cancer cells represents a major challenge in the clinical cure of advanced and metastatic cancers. CD24 has been reported to be a marker for a p...

Journal: :Journal of clinical pathology 2011
Sara Ricardo André Filipe Vieira Renê Gerhard Dina Leitão Regina Pinto Jorge F Cameselle-Teijeiro Fernanda Milanezi Fernando Schmitt Joana Paredes

BACKGROUND AND AIM The study of CD44/CD24 and ALDH1 expression is the most accurate method to identify cancer stem cells (CSC) from breast cancer populations. However, the overlap between CD44(+)CD24(-/low) and ALDH1(high) CSC phenotypes in breast cancer seems to be very small, as well as their distribution among intrinsic breast cancer subtypes. Due to this discrepancy, it is imperative to imp...

2015
Nicholas A. Fairbridge Thomas M. Southall D. Craig Ayre Yumiko Komatsu Paula I. Raquet Robert J. Brown Edward Randell Christopher S. Kovacs Sherri L. Christian Pratibha V. Nerurkar

CD24 is a glycophosphatidylinositol (GPI)-linked cell surface receptor that is involved in regulating the survival or differentiation of several different cell types. CD24 has been used to identify pre-adipocytes that are able to reconstitute white adipose tissue (WAT) in vivo. Moreover, we recently found that the dynamic upregulation of CD24 in vitro during early phases of adipogenesis is nece...

Journal: :Experimental oncology 2015
S V Chekhun T V Zadvorny Yu O Tymovska M F Anikusko O E Novak L Z Polishchuk

AIM To determine frequency of tumors with immunohistochemical markers of cancer stem cells (CSC) CD44+/CD24- in patients with breast cancer (BC) of different molecular subtype and to evaluate their prognostic value. OBJECT Surgical material of 132 patients with BC stage I-II, age from 23 to 75 years, mean age - 50.2 ± 3.1 years was studied. METHODS Clinical, immunohistochemical (expression ...

2015
Nika Shakiba Carl A White Yonatan Y Lipsitz Ayako Yachie-Kinoshita Peter D Tonge Samer M I Hussein Mira C Puri Judith Elbaz James Morrissey-Scoot Mira Li Javier Munoz Marco Benevento Ian M Rogers Jacob H Hanna Albert J R Heck Bernd Wollscheid Andras Nagy Peter W Zandstra

Reprogramming is a dynamic process that can result in multiple pluripotent cell types emerging from divergent paths. Cell surface protein expression is a particularly desirable tool to categorize reprogramming and pluripotency as it enables robust quantification and enrichment of live cells. Here we use cell surface proteomics to interrogate mouse cell reprogramming dynamics and discover CD24 a...

2015
Jian Huang Yaqi Yang Zibin Liang Miaomiao Kang Ying Kuang Feng Li

The cluster of differentiation 24 (CD24) Ala57Val polymorphism has been implicated as a risk factor for multiple sclerosis (MS) and systemic lupus erythematosus (SLE); however, genetic studies have produced controversial results. A meta-analysis was performed on this topic. We used odds ratio (OR) and 95% confidence interval (95% CI) to investigate the strength of association. Eleven studies fr...

Journal: :Cancer research 2007
Chenwei Li David G Heidt Piero Dalerba Charles F Burant Lanjing Zhang Volkan Adsay Max Wicha Michael F Clarke Diane M Simeone

Emerging evidence has suggested that the capability of a tumor to grow and propagate is dependent on a small subset of cells within a tumor, termed cancer stem cells. Although data have been provided to support this theory in human blood, brain, and breast cancers, the identity of pancreatic cancer stem cells has not been determined. Using a xenograft model in which primary human pancreatic ade...

2010
Zeshaan Rasheed Qiuju Wang William Matsui

Cancer stem cells (CSCs) have been identified in a growing number of malignancies and are functionally defined by their ability to undergo self-renewal and produce differentiated progeny. These properties allow CSCs to recapitulate the original tumor when injected into immunocompromised mice. CSCs within an epithelial malignancy were first described in breast cancer and found to display specifi...

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