Lymphocyte numbers are tightly regulated; with acute lymphopenia, T cell numbers are reestablished through lymphopenia-induced proliferation. In contrast to the costimulation requirements of antigen-driven proliferation, a number of costimulatory molecules are not required for lymphopenia-induced proliferation. However, the requirement for major histocompatibility complex (MHC)-T cell receptor ...

Pneumonia caused by Mannheimia haemolytica is an important disease of cattle (BO), domestic sheep (DS, Ovis aries) and bighorn sheep (BHS, Ovis canadensis). Leukotoxin (Lkt) produced by M. haemolytica is cytolytic to all leukocyte subsets of these three species. Although it is certain that CD18, the beta subunit of beta(2) integrins, mediates Lkt-induced cytolysis of leukocytes, whether CD18 of...

PURPOSE Corneal abrasion results in an inflammatory response characterized by leukocyte emigration into the corneal stroma. Adhesion molecules play a critical role in leukocyte emigration to wound sites, but differences are evident in different vascular beds. In this study, the contributions of two families of adhesion molecules to neutrophil emigration into the cornea were investigated. METH...

Abstract Leukocyte recruitment and their mediated inflammatory responses are critical for cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Blocking leukocyte in mouse knockouts (KO) of beta2 integrin (CD18) or blocking CD18 with antibodies multiple animals significantly reduced infarct size after I/R However, the cell-specific contribution to injury is unknown. I...

INTRODUCTION Spondyloarthritis (SpA) comprises a group of diseases often associated with HLA-B27 and characterized by inflammation of the entheses and joints of the axial skeleton. The inflammatory process in SpA is presumably driven by innate immune cells but is still poorly understood. Thus, new tools for monitoring and treating inflammation are needed. The family of CD18 integrins is pivotal...

Human neonatal neutrophils manifest decreases in mobility, adherence, and emigration compared with adult neutrophils that may contribute to the increased susceptibility of neonates to infection. In a developmental rabbit model, we show a reduced ability of neutrophils from 1-day-old rabbit pups to emigrate to inflamed peritoneium (3.7 +/- 0.35 x 10(6) neutrophils/mL peritoneal exudate) compared...

Abstract Background Inflammation is believed to influence human colorectal carcinogenesis and may have an impact on prognosis survival. The mucosal immunophenotype in dogs with cancer poorly described. aim of this study was investigate whether the density, distribution grade tumor-infiltrating immune cells (TIIs) are different normal colonic tissue vs benign stages (adenomas) malignant (adenoca...

Leukocyte adhesion deficiency type 1 (LAD1) is a rare congenital immunodeficiency disease. The cause of disease determined to be the mutations in ITGB2 gene that codes for CD18, beta chain beta-2 integrins, leads decreased expression or functioning CD18. This severe impairment leukocyte vascular wall and migration sites infection inflammation. LAD1 has also been associated with inhibition inter...