Endophytic microorganisms are recognized as potential source of novel chemical molecules that might be useful in the treatment of infectious diseases. This study was conducted with the aim to isolate and identify endophytic bacteria from medicinal plants recommended for cancer therapy with a potential to produce L-asparaginase. Five different plants were selected to enhance diversity as Cathara...

Abstract. Lay CS, Agustina I, Astuti P, Hertiani T. 2023. Cytotoxic screening of endophytic fungi associated with Catharanthus roseus. Biodiversitas 24: 2716-2722. Despite the advancements in cancer therapy, there is still a need for new anticancer agents. Due to tremendous range chemical compounds that create, they have become crucial component current drug development process. The aim this st...

Natural products have long served as both a source and inspiration for pharmaceuticals. Modifying the structure of a natural product often improves the biological activity of the compound. Metabolic engineering strategies to ferment "unnatural" products have been enormously successful in microbial organisms. However, despite the importance of plant derived natural products, metabolic engineerin...

Vinblastine and vincristine (the antileukemic agents) were isolated, in a pure form, from Catharanthus roseus L. Don., cultivated in Egypt, by several chromatographic techniques. Five modified methods for the preparation of total alkaloids were carried out. All the isolated mixtures were evaluated by HPLC and HPTLC analyses. The antineoplastic alkaloids; vinblastine and vincristine, were isolat...

Every year over 1.5 million men develop prostate cancer and it is also a significant cause of mortality among men. There are multiple factors upregulating cancer, which includes mutation in the genetics, ethnicity or hereditary. Out 23 MMPs, there 4 MMPs mostly upregulated cancer. function by deteriorating several proteins present extracellular matrix. Catharanthus roseus medicinal plant has an...