Four types of bovine liver catalase (CAT) derivatives, succinylated (Suc-CAT), galactosylated (Gal-CAT), mannosylated (Man-CAT), and polyethylene glycol conjugate (PEG-CAT), were synthesized and their pharmacokinetics and therapeutic potential in a hepatic ischemia/reperfusion injury model were studied in mice. About 90% of the CAT enzymatic activity was retained after chemical modification. Bi...

To determine whether overexpression of antioxidant enzymes in lung epithelial cells prevents damage from oxidant injury, stable cell lines were generated with complementary DNAs encoding manganese superoxide dismutase (MnSOD) and/or catalase (CAT). Cell lines overexpressing MnSOD, CAT, or MnSOD + CAT were assessed for tolerance to hyperoxia or paraquat. After exposure to 95% O(2) for 10 d, 44 t...

Catalase, an endogenous antioxidant enzyme, is responsible for regulating reactive species levels. Several epidemiologic studies have suggested that single nucleotide polymorphism in catalase gene may be associated with many diseases. The genotype of CAT (-21 A/T) point mutation in promoter region of catalase gene was determined by polymerase chain based restriction fragment length polymorphism...

In this study, the synthesis of ceria (CeO2) nanoparticles (NPs) was examined by the biosynthesis method. Then, enzyme-like features of synthesized nanoceria were examined. Peroxidase enzyme from fig (Ficus carica) was used as a synthesis and stabilizer reagent. Furthermore, it was investigated whether the obtained nanoceria has superoxide dismutase (SOD), catalase (CAT) and peroxidase (POX) ac...

Rootstocks of fruit trees, commonly used to regulate growth, precocity, fertility, and yield, can also be used to solve problems associated with soils pollution such as copper excess. Despite their potential use for phytoremediation, information on the physiological, biochemical, and molecular aspects of heavy metal toxicity stress on fruit tree rootstocks remains limited. In this study of Prun...

Infertility is the failure of a couple to engender after endeavouring at least one full year of unprotected intercourse. It has been reported that reactive oxygen species contributed to pathogenesis of various disease. To inactivate ROS cells biosynthesise several antioxidant enzymes, one of them is catalase which contributes H2 O2 to H2 O and O2 . This study set out to delineate the associatio...

Submit Manuscript | http://medcraveonline.com Abbreviations: ANOVA: Analysis of Variance; CAT: Catalase; GSH: Glutathione; GSSG: Oxidized Glutathione; GPx: Glutathione Peroxidase; GR: Glutathione Reductase; LPO: Lipid Peroxidation; Lipofuscin (LIF); ROS: Reactive Oxygen Species; SOD: Superoxide Dismutase; PMS: Phenazinemethosulphate; NBT: Nitoblu Tetrazolium; YC: Young Control; YEx: Young Exper...

Abbreviations: ROS: Reactive oxygen species; H2O2: Hydrogen peroxide; CAT: Catalase; POD: peroxidase; APX: Ascorbic Acid Peroxidase; GR: Glutathione Reductase; AsA-GSH: Ascorbate-Glutathione; ASC: Reduced form of Ascorbate; DHA: Dehydroascorbate; MDHAR: Monodehydroascorbate Reductase; DHAR: Dehydroascorbate reductase; GSH: Reduced Glutathione; GSSG: Oxidized Glutathione; PDA: Potato Dextrose Ag...

Present study aims to assess the effect of Sublethal dose of the commercial formulations of Cypermethrin (insecticide) and Oxyfluorfen (herbicide). Laboratory study was conducted in a natural Soil and Cow Dung in order to measure effect of these chemicals on activities of stress enzymes viz., Glutathione, Catalase (CAT) and LPO/MDA for a period of 90 days. The activity of Glutathione and CAT wa...

Plants co-ordinate information derived from many diverse external and internal signals to ensure appropriate control of gene expression under optimal and stress conditions. In this work, the relationships between catalase (CAT) and H2O2 during drought in wheat (Triticum aestivum L.) are studied. Drought-induced H2O2 accumulation correlated with decreases in soil water content and CO2 assimilati...