The adoption of new treatment modalities remains crucial as lung cancer has one the lowest survival rates, along with liver and pancreatic cancer. Bortezomib is a proteasome inhibitor that higher anticancer effect in combination therapies. Therefore, aim this study to investigate whether bortezomib could have additional when combined cyclin-dependent kinase (CDK) inhibitor-roscovitine vitro. Ap...

Ipconazole is an antifungal agrochemical widely used in agriculture against seed diseases of rice, vegetables, and other crops; due to its easy accumulation the environment, it poses a hazard human, animal, environmental health. Therefore, we investigated cytotoxic effect ipconazole on SH-SY5Y neuroblastoma cells using cell viability tests (MTT), ROS production, caspase3/7 activity, molecular a...

Gastric cancer is one of the most common malignancies with a high mortality rate world. This study intends to make clear role and mechanism Scutellarin (Scu), flavonoid isolated from Erigeron breviscapus (Vant.) Hand.-Mazz, in regulating evolvement gastric cancer. We selected different doses Scu treat cells (MGC-803 AGS). Then, cell counting kit-8 (CCK8) assay was conducted verify proliferation...

The P38 mitogen-activated protein kinase (MAPK) signal transduction pathway is widespread in organisms and plays important roles immune activities. infection mechanism of environmental gram-negative bacteria on crustaceans an scientific problem. In this study, the cDNA full-length sequence Portunus trituberculatus (PtP38) was cloned its structure analyzed by bioinformatics methods. To study fun...

The air dried leaves of Laurus nobilis cultivated in Egypt were extracted by petroleum ether followed methylene chloride then ethyl acetate and finally methanol. preliminary cytotoxic screening these extracts against Hep-G2 using vinblastine sulfate (IC50= 2.93 ?g/ml) as standard showed that ether, exhibited strong activity 10.6, 5.96 3.80 ?g/ml, respectively) while the methanolic extract moder...

To investigate the protective effect of irudin on renal interstitial injury caused by proteinuria regulating core fucosylation modification using model microfluidic chip. Application tissue engineering soft lithography technology preparation with cavity proximal small pipe, tube Zhou Wei vascular lumen and area Polydimethylsiloxane chip material, in tubes each Human tubular epithelial cells umb...

Purpose: To investigate the effect of Pinellia polysaccharide on airway remodeling in cough-variant asthmatic rats, and involvement PI3K/AKT signal route process.
 Methods: Seventy-five Sprague-Dawley (SD) rats were assigned to 5 groups: blank control, model, low-dose (100 mg/kg), medium-dose (200 mg/kg) high-dose (400 groups, each with 15 rats. Immunoblot assay was employed measure relati...

Abstract INTRODUCTION The median survival of Glioblastoma (GBM) patients is less than two years with the standard care maximal surgical resection, radiation, and temozolomide (TMZ) chemotherapy. Protein Arginine Methyltransferase 5 (PRMT5), which regulates cellular functions by symmetrically di-methylating arginine residues, overexpressed in GBM. Inhibiting PRMT5 induces apoptosis differentiate...

Chemoresistance is one of the main factors treatment failure cervical cancer (CC). Here, we intended to discover role and mechanism miR-509-5p in paclitaxel chemoresistance CC cells. RT-PCR was conducted verify miR-509-3p expression. HCC94 C-33A paclitaxel-resistant cell models were constructed. Additionally, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay flow cytometr...

GC/MS analysis of hydro-distillated essential oil (1.9% v/w) from fresh leaves Laurus nobilis cultivated in Egypt revealed the presence 81 components which 59 compounds were identified, identified represent 96.3 % composition. The major constituents 1,8-cineole (27.41%), linalool (19.37%), ?-terpinyl acetate (14.65%), methyl eugenol (7.73%), ?-terpineol, (2.84%), terpinen-4-ol (2.09%), elemicin...