The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell line HT-29. HCT inhibited HT-29 cell viability in a dose- and time-dependent m...

Today, drug resistance is one of the major problems in fight against cancer. Therefore, combination of therapeutic strategies was raised to effectively improve disease prognosis. In this regard, silver nanoparticles (AgNPs) are considered significant due to their anticancer properties. This study aimed to return sensitivity to cisplatin to A2780 cisplatin-resistance cell lines in the presence o...

Background and objectives: Achillea is an ancient medicinal herb. The genus comprises about 100 species which are mostly distributed in northern hemisphere and some have been investigated for different biological activities. There are also several reports in Iranian Traditional Medicine (ITM) texts about its anti-tumor effect. The cytotoxic activity of the methanol extract of Achil...

Introduction: The leaves of Altingia excelsa were found to strongly inhibit SP-C1 human tongue cancer cell lines. This study was focused on identifying antiproliferative compounds in A. and assesment their action mechanism. Methods: Extracts Methanol fractionated based solvent polarity using n-hexane, ethyl acetate, water. anti-proliferative testing tested vitro against lines the MTT assay. Iso...

The amyloid precursor protein (APP) undergoes a variety of modifications through enzymatic cleavage leading to the formation of pro-Alzheimer’s disease (AD) and anti-AD biologically active peptides. One such cleavage product, APP ΔC31 results from the caspase cleavage of the full length APP protein (APP695) at amino acid Asp664 as well as the concomitant formation of the 31 amino acid C-termina...

BACKGROUND Calreticulin (CRT) can bind to Fas ligand (FasL) and inhibit Fas/FasL-mediated apoptosis of Jurkat T cells. However, its effect on neuronal cell apoptosis has not been investigated. PURPOSE We aimed to evaluate the neuroprotective effect of CRT following ischemia-reperfusion injury (IRI). METHODS Mice underwent middle cerebral artery occlusion (MCAO) and SH-SY5Y cells subjected t...

Ewing sarcoma is a rare malignancy occurring in childhood and adolescence which has a prognosis of about 50% long-term event-free survival, depending on risk factors such as tumor volume, initial metastases at the time of diagnosis and tumor response to presurgical chemotherapy. In order to tailor therapy to the individual patient, new prognostic factors need to be identified. In this study, we...

Melanoma has been reported a contemporary malignant cancer. Here, anti-cancer effects of sea cucumber extract (SCE) have been examined on melanoma cells and compared with dacarbazine. MTT assay and morphological analysis were performed to evaluate cytotoxic effects of methanolic SCE Also, several methods were exerted to detect cell dying by SCE and dacarbazine. The MTT assay showed that B16F10 ...

Thesis Abstract In the last few decades properties of silver compounds have been interest as potential cancer treatments. The present work was designed to study effect new conjugated caffeic and folic acid with nanoparticle definite molecular size applied without gamma radiation exposure, an antitumor agent against experimentally induced Ehrlich tumor attempted identify their mechanisms action ...

Purpose: To determine the inhibitory potential of betulinic acid on pro-survival signaling pathway in glioblastoma.Methods: Changes viabilities glioma cells and primary astrocytes were measured using 3-(4, 5dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Apoptotic changes analyzed Hoechst 33342 staining Annexin V-FITC/PI kits. Western blotting was used for assaying protein e...