نتایج جستجو برای: casp8

تعداد نتایج: 645  

Journal: :Proteins: Structure, Function, and Bioinformatics 2009

Journal: :Proteins 2009
Srivatsan Raman Robert Vernon James Thompson Michael Tyka Ruslan Sadreyev Jimin Pei David Kim Elizabeth Kellogg Frank DiMaio Oliver Lange Lisa Kinch Will Sheffler Bong-Hyun Kim Rhiju Das Nick V Grishin David Baker

We describe predictions made using the Rosetta structure prediction methodology for the Eighth Critical Assessment of Techniques for Protein Structure Prediction. Aggressive sampling and all-atom refinement were carried out for nearly all targets. A combination of alignment methodologies was used to generate starting models from a range of templates, and the models were then subjected to Rosett...

2009
M. Borg W. Boomsma P. Røgen K. Stovgaard T. Hamelryck

The prediction of the 3-dimensional structure of a protein given its chemical composition (that is, its amino acid sequence), remains an elusive problem in spite of decades of research efforts. The rate of progress in the field is even stagnating, and much of the improvements seen in the last couple of years can be attributed to larger databases of experimentally determined protein structures, ...

Journal: :Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2001
Alan Milburn

A CASH injection to boost midwifery services throughout England will improve facilities but may not ease staffing crises, midwives fear.

2015
Alexandra Iulia Irimie Cornelia Braicu Oana Zanoaga Valentina Pileczki Claudia Gherman Ioana Berindan-Neagoe Radu Septimiu Campian

Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation of SSC-4 human oral squamous cell carcinoma (OSCC), the effect being dose- and time-dependent. In parallel was observed the activation of apoptosis and autophagy, in response to EGCG exposure in SSC-4 cells. Treatment with EGCG activa...

2008
T. Poplawski K. Tomaszewska M. Galicki Z. Morawiec J. Blasiak

DNA methylation is recognized as the most important epigenetic change in the malignant transformation. It includes global hypermethylation and the hypermethylation of CpG islands localized in the regulatory regions of most human genes [1, 2]. Methylated cytosine may undergo spontaneous deamination, producing a C → T transition, which, if in the promoter, may significantly affect the level of ex...

2012
FRANCISCO JOSÉ TINAHONES NURIA BARBARROJA

RESEARCH DESIGN AND METHODSdThe expression levels of initiator (CASP8/9) and effector (CASP3/7) caspases as well as antiapoptotic B-cell lymphoma (BCL)2 and inflammatory markers were assessed in visceral (VAT) and subcutaneous (SAT) adipose tissue from patients with different degrees of obesity and without insulin resistance or diabetes. Adipose tissue explants from lean subjects were cultured ...

2009
Daniel A. Keedy Christopher J. Williams Jeffrey J. Headd W. Bryan Arendall Vincent B. Chen Gary J. Kapral Robert A. Gillespie Jeremy N. Block Adam Zemla David C. Richardson Jane S. Richardson

The other 90% of the protein: Assessment beyond the Cas for CASP8 template-based and high-accuracy models Daniel A. Keedy, Christopher J. Williams, Jeffrey J. Headd, W. Bryan Arendall III, Vincent B. Chen, Gary J. Kapral, Robert A. Gillespie, Jeremy N. Block, Adam Zemla, David C. Richardson, and Jane S. Richardson* 1Department of Biochemistry, Duke University Medical Center, Durham, North Carol...

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function paginate(evt) { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term pg=parseInt(evt.target.text) var data={ "year":filter_year, "term":term, "pgn":pg } filtered_res=post_and_fetch(data,url) window.scrollTo(0,0); } function update_search_meta(search_meta) { meta_place=document.getElementById("search_meta_data") term=search_meta.term active_pgn=search_meta.pgn num_res=search_meta.num_res num_pages=search_meta.num_pages year=search_meta.year meta_place.dataset.term=term meta_place.dataset.page=active_pgn meta_place.dataset.num_res=num_res meta_place.dataset.num_pages=num_pages meta_place.dataset.year=year document.getElementById("num_result_place").innerHTML=num_res if (year !== "unfilter"){ document.getElementById("year_filter_label").style="display:inline;" document.getElementById("year_filter_place").innerHTML=year }else { document.getElementById("year_filter_label").style="display:none;" document.getElementById("year_filter_place").innerHTML="" } } function update_pagination() { search_meta_place=document.getElementById('search_meta_data') num_pages=search_meta_place.dataset.num_pages; active_pgn=parseInt(search_meta_place.dataset.page); document.getElementById("pgn-ul").innerHTML=""; pgn_html=""; for (i = 1; i <= num_pages; i++){ if (i===active_pgn){ actv="active" }else {actv=""} pgn_li="
  • " +i+ "
  • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->