In addition to hemorrhagic cystitis, Fanconi Syndrome is a serious clinical side effect during ifosfamide (IFO) therapy. Fanconi syndrome is a generalized dysfunction of the proximal tubule which is characterized by excessive urinary excretion of glucose, phosphate, bicarbonate, amino acids and other solutes excreted by this segment of the nephron including L-carnitine. Carnitine is essential c...

Twelve sows were used to examine the effects of feeding L-carnitine from artificial insemination to mid-gestation on maternal circulating IGF-I and carnitine concentrations and fetal growth. Supplementing L-carnitine did not influence the serum concentration of IGF-I. However, sows that were fed carnitine had increased circulating plasma free carnitine. Litters from sows fed L-carnitine were he...

The in vivo effects of dexamethasone administration on liver and extrahepatic tissue carnitine concentrations were assessed in 48-h-starved rats. In heart and kidney, but not in liver, dexamethasone significantly increased total carnitine concentration. Acute (2.5 h) treatment with 2-tetradecylglycidate (TDG), a specific inhibitor of carnitine palmitoyl transferase 1, not only increased total h...

background: l-carnitine may prevent the incidence of aki by its antioxidant effects and improving circulation in ischemic conditions. the goal of this trial was to evaluate the impact of l-carnitine on contrast-induced nephropathy in patients undergoing elective pci. methods: totally, the patients were randomly allocated to 2 groups. the treatment group received 1 g of l-carnitine orally 3 time...

Background: Ventricular septal defect (VSD) and Atrial (ASD) are the most common congenital heart disease (CHD). This study aimed to improve of health status, quality life, morbidity mortality pediatrics patient with ASDs. Methods: was a cohort carried out at Pediatric Cardiology Unit Zagazig University hospitals during period from October 2019 2020 Included 30 children up 2 years age were foll...

Previous studies from this laboratory and by Wittels and Bressler have suggested that myocardial carnitine depletion and an accompanying decrease in fatty acid oxidation may contribute to the myocardial disease associated with diphtheria. In addition, administration of carnitine was found to prolong survival of diphtheritic guinea pigs and improve ventricular function in diphtheritic dogs. The ...

Carnitine and its derivatives have recently been shown to protect cardiac metabolism and function in ischemic heart disease and other clinical conditions of myocardial ischemia. Potential mechanisms of this effect include an increase in glucose metabolism, a reduction of toxic effects of long-chain acyl-CoA and acyl-carnitine in myocytes, an increase in coronary blood flow and anti-arrhythmic e...

A wide range of morphological and biochemical changes occur in the central nervous system with increasing age. L-carnitine, a naturally occurring compound, plays a vital role in fatty acid transport across the mitochondrial membrane. L-carnitine (300 mg/kg body wt/day) was administered intraperitoneally to young and old male Wistar rats for 7, 14, and 21 days. Carnitine, dopamine, epinephrine, ...

  Twelve weeks of daily l-carnitine and carbohydrate feeding in humans increases skeletal muscle total carnitine content, and prevents body mass accrual associated with carbohydrate feeding alone. Here we determined the influence of L-carnitine and carbohydrate feeding on energy metabolism, body fat mass and muscle expression of fuel metabolism genes. Twelve males exercised at 50% maximal oxyge...

BACKGROUND AND AIMS Atherosclerotic cardiovascular disease is the most common cause of mortality in patients with end-stage kidney disease. Chronic kidney disease patients often exhibit a deficiency in L-carnitine due to loss during hemodialysis (HD). We studied the effects of L-carnitine supplementation on brachial-ankle pulse wave velocity (baPWV), a marker of atherosclerosis, in HD patients....