Abstract Background Fatty acid oxidation (FAO) provides an important source of energy to promote the growth leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme essential step FAO, can facilitate cancer metabolic adaptation. Previous reports demonstrated that CPT1a acts as potential molecular target in solid tumors and hematologic disease. However, no systematic stud...

Carnitine palmitoyltransferase II (CPT-2) deficiency, an autosomal recessive disorder of fatty acid oxidation, can be detected by newborn screening using tandem mass spectrometry (TMS). Our case was a boy born at 38 weeks and 6 days of gestation via normal vaginal delivery; his elder sister was affected with CPT-2 deficiency. Acylcarnitine (AC) was analyzed in both dried blood spots (DBS) and s...

acyl-CoA synthetase and carnitine acyltransferase I not only exhibit the greatest adaptive responses during development but also show the most dramatic increases in activity in the livers of adult rats subjected to experimental conditions known to result in an increase in hepatic fatty acid degradation (P. A. Chalk & E. Bailey, unpublished work). It seems possible that these enzymes may fulfil ...

PPAR-α plays a key role in lipid metabolism; it enhances fatty acid oxidation (FAO) and ketogenesis. Pharmacological PPAR-α activation improves insulin sensitivity and reduces food intake, but its mechanisms of action remain unknown. We here report that intraperitoneal (IP) administration of the PPAR-α agonist Wy-14643 (40 mg/kg BW) reduced food intake in adult male rats fed a high-fat diet (HF...

BACKGROUND In carnitine palmitoyltransferase I (CPT-I) deficiency (MIM 255120), free carnitine can be increased with no pathologic acylcarnitine species detectable. As inclusion of CPT-I deficiency in high-risk and newborn screening could prevent potentially life-threatening complications, we tested whether CPT-I deficiency might be diagnosed by electrospray ionization-tandem mass spectrometry ...

Pregnancy is characterized by a complexity of metabolic processes that may impact fetal development and ultimately, infant health outcomes. However, our understanding of whole body maternal and fetal metabolism during this critical life stage remains incomplete. The objective of this study is to utilize metabolomics to profile longitudinal patterns of fasting maternal metabolites among a cohort...