How is Ran involved in nuclear transport? Cargo is transported through pores in the nuclear envelope, in association with carriers that bind to pore proteins called nucleoporins. A Ran–GTP gradient across the envelope is created by the asymmetric distribution of the GTPase activating protein known as RanGAP, which is in the cytosol, and of the guanine nucleotide exchange factor RanGEF in the nu...

12 Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model of neuron-wide transport, sometimes called the “sushi-belt model” (Doyle and Kiebler, 2011). Current theories and experiments are based on ...

This paper concentrates on the problem of the air cargo space management strategy with a comprehensive, abstract and simplified way, on the basis of the actual characteristics of transport demand in China's air cargo market. We focus on the urgent transportation of goods and general cargo transport whose time requirements are different. The paper first proposes a single-leg cargo space manageme...

http://www.aic.gov.au Adam Graycar Director Many companies suffer losses through cargo theft, particularly small businesses, yet it is an area of business crime that receives scant attention. A single truckload of cargo can be worth as much as $3 million. The risk of theft, especially if the goods have a black market value, is very real. Worldwide, the direct cost of cargo theft is estimated at...

Plasma membrane proteins that enter cells by clathrin-independent endocytosis (CIE) are sorted either to lysosomes for degradation or recycled back to the plasma membrane. Expression of some MARCH E3 ubiquitin ligases promotes trafficking of CIE cargo proteins to lysosomes by ubiquitylating the proteins. Here, we show that co-expression of the ubiquitin-specific protease TRE17/USP6 counteracts ...

BACKGROUND Incorporation of secretory proteins into ER-derived vesicles involves recognition of cytosolic signals by the COPII coat protein, Sec24. Additional cargo diversity is achieved through cargo receptors, which include the Erv14/Cornichon family that mediates export of transmembrane proteins despite the potential for such clients to directly interact with Sec24. The molecular function of...

12 13 The authors declare that no competing interests exist. 14 2 Abstract 15 Autophagy is a major pathway for the clearance of harmful material from the cytoplasm. 16 During autophagy cytoplasmic material is delivered into the lysosomal system by organelles 17 called autophagosomes. Autophagosomes form in a de novo manner and, in the course of their 18 formation, isolate cargo material from th...

Kinesin-based cargo transport in cells frequently involves the coordinated activity of multiple motors, including kinesins from different families that move at different speeds. However, compared to the progress at the single-molecule level, mechanisms by which multiple kinesins coordinate their activity during cargo transport are poorly understood. To understand these multimotor coordination m...