Mailing Address: Roberto Jorge da Silva Franco • Rua Carlos Guadanini, 1805 18610-120 – Botucatu, SP Brazil E-mail: [email protected] An estimated 10% of the American population has some degree of renal disease, although asymptomatic. In Brazil, no data are available on the prevalence of chronic renal disease. A number of studies show a direct and close relationship between the degree of re...

OBJECTIVES To correlate cardiovascular risk factors (e.g., hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, sedentariness) in childhood and adolescence with the occurrence of cardiovascular disease. SOURCES A systematic review of books and selected articles from PubMed, SciELO and Cochrane from 1992 to 2012. SUMMARY OF FINDINGS Risk factors for atheroscleros...

Inflammation occurs in the vasculature as a response to injury, lipid peroxidation, and perhaps infection. Various risk factors, including hypertension, diabetes, and smoking, are amplified by the harmful effects of oxidized low-density-lipoprotein cholesterol, initiating a chronic inflammatory reaction, the result of which is a vulnerable plaque, prone to rupture and thrombosis. Epidemiologica...

To determine the relation between plasma triglyceride levels and the risk of incident cardiovascular disease, the semiquantitative techniques of meta-analysis were applied to 17 population-based prospective studies of triglyceride and cardiovascular disease. Sixteen of these studies represented 2,445 events among 46,413 Caucasian men followed for an average period of 8.4 years, and 5 studies re...

Cardiovascular disease is the leading cause of mortality and disability in the western world. In the last years, the accumulation of evidence coming from both retrospective and prospective clinical studies has led to an increased interest in the potential role of mild hyperhomocysteinemia as a major, independent risk factor for cardiovascular disease. The present paper reviews the position of h...

The main guiding editorial principle of Heart is to improve the care of patients with cardiovascular disease by publishing high-impact innovative clinically relevant original cardiovascular research. However, it can be difficult to specify exactly what defines “high-impact”. In addition to the traditional Impact Factor ( Journal Citation Reports, Thomson Reuters, 2015) used for medical journals...

At this point, each aspect of the graph can be individually modified in some way. Choices governing color, tone, texture, grid display, cell spacing, row and column orientation, label dimension and orientations, character fonts, and other items may be approached by the preset options or the custom route. Preset options are coordinated schemes which generally display the graph well; however, the...

There is increasing evidence that certain microbial agents may have an etiopathogenic role in the development of atherothrombosis. Helicobacter pylori, a bacterium that causes peptic ulcer disease, has been suggested as one of the microbes involved in the development of atherothrombosis. This hypothesis is based on the following observations: a) a higher prevalence of Helicobacter pylori infect...

References 1. Fabiato A: Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac purkinje cell. J Gen Physiol 1985;85:247-289 2. Movsesian MA, Bristow MR, Krall J: Ca 2+ uptake by cardiac sarcoplasmic reticulum from patients with idiopathic dilated cardiomyopathy. Circ Res 1989;65:1141-1144 3. M...