This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. Thei...

Moderate weight loss improves metabolic and cardiovascular risk factors and prevents the progression to Type 2 diabetes. Furthermore, a healthy lifestyle is associated with lower cardiovascular mortality, whereas sustained weight loss and increased fitness are both associated with reduced cardiovascular mortality. Currently available antiobesity drugs have been shown to deliver moderate weight ...

In the contemporary practice of treatment of myocardial infarction (MI), beta-blocking agents have no mortality benefit but they do reduce recurrent myocardial infarction (MI) and angina. However, this comes at the expense of an increase in heart failure, cardiogenic shock and drug discontinuation as shown by a recent meta-analysis published online in the American Journal of Medicine in June 20...

Molecular imaging with targeted contrast agents by magnetic resonance imaging (MRI) allows for the noninvasive detection and characterization of biological changes on a molecular level. In this article, the principles of molecular MRI and its applications in cardiovascular diseases are reviewed. First, basic properties of positive and negative contrast agents are introduced and their effect on ...

INTRODUCTION This paper describes a planned process evaluation of the Use of a Multidrug Pill In Reducing Cardiovascular Events (UMPIRE) trial, one of several randomised clinical trials taking place globally to assess the potential of cardiovascular drugs as a fixed-dose combination (polypill) in cardiovascular disease prevention. A fixed-dose combination may be a promising strategy for promoti...

purpose: deformability/rheologic behavior of erythrocytes are related to near-surface membrane fluidity. specific agents can increase erythrocyte membrane fluidity in order to adjust hemodynamics in cardiovascular diseases. grapefruit flavanone naringenin has been proposed for potential use in an alternative therapy of cardiovascular conditions. in respect to this, we assessed here effects o...

Macromolecular gadolinium (Gd)(III) complexes have a prolonged blood circulation time and can preferentially accumulate in solid tumors, depending on the tumor blood vessel hyperpermeability, resulting in superior contrast enhancement in magnetic resonance (MR) cardiovascular imaging and cancer imaging as shown in animal models. Unfortunately, safety concerns related to these agents' slow elimi...

One of the goals of medicinal chemistry research and drug discovery is to provide a rationalbasis for the design of new medicinal agents. Organic compounds and their reactions have beenutilized by people since antiquity. Due to the increasing demand for bioactive molecules, organicchemists are increasingly required to synthesize new compounds of biological interest. AsBenzimidazoles are very us...

Abstract Cardiovascular disease is the leading cause of mortality worldwide, affecting a wide range patients at different stages across cardiovascular continuum. Hypertension one earliest risk factors in this continuum and can be controlled most with currently available antihypertensive agents. However, goals are often not met because treatments optimized terms tailoring therapy to individual b...