Changes in size, morphology, and certain relevant biochemical components of hearts from spontaneously hypertensive and normal Wistar rats were studied comparatively. Groups of rats were killed at stages which represented developing and stable cardiac hypertrophy and approaching cardiac failure. Mitochondrial content was determined by comparing cytochrome oxidase activity per milligram of heart ...

A 15-month-old girl, born to the consanguineous parents, was referred with the sign of massive splenomegaly associated with thrombocytopenia and anemia. Plasma Chitotriosidase estimation was carried out as a screening test and was found to be normal with reduced activity of β-glucosidase in leucocytes suggestive of Gaucher disease. At the age of 4 years, severe osteoporosis and cardiomegaly wit...

Cantu syndrome is a rare congenital disorder characterized by hypertrichosis, osteochondrodysplasia, cardiomegaly, macrocephaly, short body stature, prominent or enlarged forehead, wide set and bulging eyes, loose skin with wrinkled palms and soles of the feet, hyperextensible joints, wide ribs and small vertebrae. We describe a newborn with features of Cantu syndrome.

A surface electrocardiogram showing type B Wolff-Parkinson-White syndrome pattern was part of the cardiac findings in a female of 24 with florid features of tuberous sclerosis. She had cardiomegaly but no intracardiac tumour was demonstrated. Wolff-Parkinson-White syndrome, though rare, has previously been described in association with tuberous sclerosis in children but not before in adults.

Fucosidosis is a rare lysosomal storage disorder with the clinical features of mental retardation, cardiomegaly, dysostosis multiplex, progressive neurologic deterioration, and early death. The neuroradiologic findings in two patients are reported, and include abnormalities within the globus pallidus (both patients) and periventricular white matter (one patient).

A case of severe diffuse systemic sclerosis with cardiomegaly and cardiac failure is described. Treatment with D-penicillamine caused a pronounced decrease in heart size, together with clinical improvement. The use of penicillamine in scleroderma heart has not previously been reported.

CARDIOVASCULAR DISORDERS aortic anomalies aortic aneurism aortic arch, anomalies aortic valvular, anomalies cardiac congenital defects cardiomegaly cardiopathy, congenital heart conduction defects, cardiac arrhythmia, including tachycardia, atrial fibrillation, ventricular fibrillation heart conduction defects, cardiac arrhythmia, including: bradycardia, cardiac dysrhythmias mitral valve, defec...

Conditions Hypertension Diabetes Obesity CAD (eg, after MI, revascularization) Peripheral arterial disease or cerebrovascular disease Valvular heart disease Family history of cardiomyopathy in a first-degree relative History of exposure to cardiac toxins Sleep-disordered breathing Test Findings Sustained arrhythmias Abnormal ECG (eg, LVH, left bundle branch block, pathologic Q waves) Cardiomega...