COVID-19 is a novel viral infection caused by severe acute respiratory syndrome (SARS) beta-coronavirus. Epidemiological status changes dynamically as the pandemy far from ending. Several complications of presented virus may be similar to those observed in other infections. Despite lacking data, heart involvement comparable cardiac previously with SARS well Middle East Respiratory Syndrome (MER...

Cardiac glycosides are unusual in having a narrow therapeutic range, which is idiosyncratic to the individual. In view of this it is perhaps not surprising that toxicity is a common occurrence, being reported in up to 35% of digitalized patients.' There are several mechanisms which can lead to this problem. Firstly, digoxin is excreted mainly by the kidneys, and therefore, any impairment ofrena...

The current study was designed to investigate the effect of abstinence in combination with environmental enrichment (EE) on cardiac and renal toxicity induced by 2 weeks of ketamine self-administration (SA) in rodents. In Experiment 1, one group of rats underwent ketamine SA for 14 days. In Experiment 2, the animals completed 2 weeks of ketamine SA followed by 2 and 4 weeks of abstinence. In Ex...

The anthracyclines are effective and widely used antineoplastic agents. They are used to treat many types of malignancy including acute lymphoblastic leukaemia.' Their introduction has considerably improved survival, especially in childhood cancers. Signs of cardiac toxicity may develop during, soon after or many years after a course of treatment. Early toxicity is dependent principally on the ...

There has been tremendous interest in constructing in vitro cardiac tissue for a range of fundamental studies of cardiac development and disease and as a commercial system to evaluate therapeutic drug discovery prioritization and toxicity. Although there has been progress towards studying 2-dimensional cardiac function in vitro, there remain challenging obstacles to generate rapid and efficient...