Highly efficient capillary electrochromatographic separations of cardiac glycosides and other steroids are presented. Employing butyl-derivatized silica particles as stationary phase resulted in a nearly three times faster electroosmotic flow (EOF) compared to capillary electrochromatography (CEC) with octadecyl silica particles. On-column focusing with a preconcentration factor of 180 was perf...

Ovarian clear cell carcinoma (OCCC) is an aggressive neoplasm with a high recurrence rate that frequently develops resistance to platinum-based chemotherapy. There are few prognostic biomarkers or targeted therapies exist for patients with OCCC. Here, we identified that FXYD2, the modulating subunit of Na+/K+-ATPases, was highly and specifically expressed in clinical OCCC tissues. The expressio...

Overdosage with cardiac glycosides is well documented, but not usually fatal. A case is described in which cardiac arrest in asystole was associated with a serum digoxin level of 50-4 microgram/1, the highest concentration yet reported after oral administration.

The phytochemicals present in the plants are responsible for the biological activities and therapeutic properties of the various medicinal plants. They function as antioxidants in health promotion by preventing oxidant-damage which is the main cause of many diseases. The present study deals with the comparative analysis of phytochemicals in the methanolic and chloroformic leaf extracts of three...

Previous studies have shown that the toxic effects of cardiac glycosides are not manifested uniformly throughout the myocardium. The purpose of our study was to determine whether cardiac glycosides exert different effects on the right vs. left peripheral Purkinje systems and to ascertain mechanisms involved. Control in vitro measurements of paired right and left canine Purkinje fibers showed hi...

Hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that mediates the adaptation of tumor cells and tissues to the hypoxic microenvironment, has attracted considerable interest as a potential therapeutic target. Recently, HIF-1α has been recognized as the critical target of cardiac glycosides for cancer therapy, but the molecular mechanism of cardiac glycosides' inhibition ...

With Contributions by L .Brown, W.H.Barry , D.Charlemagne, E. Erdmann, A . A . L.Fox, U.Fricke, W.H.van Gilst, T.Godfraind, K.Greeff, M.Heller , Κ.-Ο. Haustein, G. Isenberg, R.Jacob, T.Kazazoglou, D . K i m , K.Kochsiek, J .M.Koomen, W.Krawietz, M.Lazdunski, L.G.Lelievre, H.Lül lmann, P.Mansicr, E.Noack, D.Noble, D.Palm, Th.Peters, H.-H.Pri l lwitz , J.F.Renaud, B.Rossi, J . A . M . Schevers, T...