PURPOSE Respiratory motion correction remains a challenge in coronary magnetic resonance imaging (MRI) and current techniques, such as navigator gating, suffer from sub-optimal scan efficiency and ease-of-use. To overcome these limitations, an image-based self-navigation technique is proposed that uses "sub-images" and compressed sensing (CS) to obtain translational motion correction in 2D. The...

One can acquire high-resolution pulmonary and cardiac images in live rodents with MR microscopy by synchronizing the image acquisition to the breathing cycle across multiple breaths, and gating to the cardiac cycle. The precision with which one can synchronize image acquisition to the motion defines the ultimate resolution limit that can be attained in such studies. The present work was perform...

An analysis of the effect of respiratory function on MR flow measures of the internal jugular vein (IJV) is presented. A novel 2D radial acquisition and reconstruction method allows for retrospective gating to both the cardiac and respiratory cycle. In-vivo scans of human volunteers verify the efficacy of the algorithm, showing increased IJV flow during inspiration and decreased flow during exp...

BACKGROUND The determination of left ventricular ejection fraction using cardiovascular magnetic resonance (CMR) requires a steady cardiac rhythm for electrocardiogram (ECG) gating and multiple breathholds to minimize respiratory motion artifacts, which often leads to scan times of several minutes. The need for gating and breathholding can be eliminated by employing real-time CMR methods such a...

UNLABELLED This study was designed to assess the prognostic value of stress myocardial perfusion SPECT with electrocardiographic (ECG) gating in patients undergoing noncardiac surgical treatment. METHODS The study included 481 consecutive patients who underwent noncardiac surgery and had been referred for preoperative myocardial perfusion scintigraphy. Myocardial scintigraphy used (99m)Tc-lab...

Introduction: Retrospective gating is a preferred strategy for the reconstruction of cardiac cine data, as it proves superior to prospective gating for capturing end-diastolic phases. These phases are especially important for accurate ejection fraction measurements, as the left atrium contracts to increase the left ventricle’s blood volume. In the present work, desirable characteristics of UNFO...

Background Cardiac MRI requires a steady cardiac rhythm for ECGgating, and multiple breath-holds to minimize respiratory artifacts. By employing a non-Cartesian parallel imaging in form of through-time radial GRAPPA [1], accelerated imaging can be performed with temporal resolutions of < 50 ms, obviating the need for gating or breath-holding. breath-holding. We tested the hypothesis that volume...

Aberrant Zn2+ homeostasis is associated with dysregulated intracellular Ca2+ release, resulting in chronic heart failure. In the failing heart a small population of cardiac ryanodine receptors (RyR2) displays sub-conductance-state gating leading to Ca2+ leakage from sarcoplasmic reticulum (SR) stores, which impairs cardiac contractility. Previous evidence suggests contribution of RyR2-independe...