Objective(s): Cirrhotic cardiomyopathy refers to cardiac muscle dysfunction caused by liver cirrhosis. Seemingly, free radicals and inflammatory factors play a critical role in the pathophysiology of cardiomyopathy. Curcumin has the anti-inflammatory, antioxidant, and anticancer properties . However, the therapeutic indications of this compound are limited due to its low absorption, rapid metab...

Computational models of cardiac electrophysiology have been used for over half a century to investigate physiological mechanisms and generate hypotheses for experimental testing, and are now starting to play a role in clinical applications. There is currently a great deal of interest in using models as diagnostic or therapeutic aids, for example using patient-specific whole-heart simulations to...

OBJECTIVES Clinical data was analyzed to find an efficient way to localize the accessory pathway in patients with ventricular preexcitation. METHODS The delta wave morphologies and ablation sites of 186 patients who underwent catheter ablation were analyzed and an algorithm ("locAP") to localize the accessory pathway was developed from the 84 data sets with a PQ interval ≤0.12s and a QRS widt...

Cardiac electrophysiology has evolved into an important subspecialty in cardiovascular medicine. This is in part due to the significant advances made in our understanding and treatment of heart rhythm disorders following more than a century of scientific discoveries and research. More recently, the rapid development of technology in cellular electrophysiology, molecular biology, genetics, compu...

Corresponding Author: Konstantinos P. Letsas, Laboratory of Cardiac Electrophysiology, “Evangelismos” General Hospital of Athens, 10676, Athens, Greece.

Embryonic stem cell-derived cardiomyocytes (ESC-CMs) hold great interest in many fields of research including clinical applications such as stem cell and gene therapy for cardiac repair or regeneration. ESC-CMs are also used as a platform tool for pharmacological tests or for investigations of cardiac remodeling. ESC-CMs have many different aspects of morphology, electrophysiology, calcium hand...

Cardiac arrhythmias can develop complex electrophysiological patterns which complexify the planning and control of therapies, especially in the context of radio-frequency ablation. The development of electrophysiology models aims at testing different therapy strategies. However, current models are computationally expensive and often too complex to be adjusted with limited clinical data. In this...